Publications by authors named "Agnes P Biju"
Article Synopsis
- * Researchers developed a radiolabeled version of Lecanemab ([I]IPC-Lecanemab) that showed stronger binding to Aβ plaques in the grey matter of postmortem AD brains compared to white matter, indicating its effectiveness.
- * The findings suggest that [I]IPC-Lecanemab could serve as a valuable PET imaging radiotracer to visualize Aβ in vivo, aiding in treatment planning and evaluating therapeutic outcomes in AD.
In an effort to further understand the challenges facing in vivo imaging probe development for the N-methyl-D-aspartate (NMDA) receptor ion channel, we have evaluated the effect of glutamate on the Alzheimer's disease (AD) brain. Human post-mortem AD brain slices of the frontal cortex and anterior cingulate were incubated with [H]MK-801 and adjacent sections were tested for Aβ and Tau. The binding of [H]MK-801 was measured in the absence and presence of glutamate and glycine.
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