Patients' perceptions of individualized care: evaluating psychometric properties and results of the individualized care scale.

Health-care organizations aim to provide patient-centred care, yet measurement of this aspect of care quality remains a challenge.This cross-sectional study investigated the reliability and validity of the bipartite Individualized Care Scale (ICSA, ICS-B) in a Canadian hip and knee arthroplasty population. Internal consistency of the ICS-A and ICS-B was high; however, factorial validity was not fully supported.

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling.

In cells infected with the Kaposi's sarcoma-associated herpesvirus (KSHV), CSL/CBF1 signaling is essential for viral replication and promotes the survival of KSHV-infected cells. CSL/CBF1 is a DNA adaptor molecule which recruits coactivator and corepressor complexes to regulate viral and cellular gene transcription and which is a major downstream effector molecule of activated Notch. The interaction of KSHV RTA and LANA with CSL/CBF1 has been shown to balance the lytic and latent viral life cycle.