Publications by authors named "Agnes Mosolygo-L"
Arabidopsis NODULIN HOMEOBOX (NDX) is a plant-specific transcriptional regulator whose role in small RNA biogenesis and heterochromatin homeostasis has recently been described. Here we extend our previous transcriptomic analysis to the flowering stage of development. We performed mRNA-seq and small RNA-seq measurements on inflorescence samples of wild-type and ndx1-4 mutant (WiscDsLox344A04) Arabidopsis plants.
View Article and Find Full Text PDFArabidopsis NODULIN HOMEOBOX (NDX) is a nuclear protein described as a regulator of specific euchromatic genes within transcriptionally active chromosome arms. Here we show that NDX is primarily a heterochromatin regulator that functions in pericentromeric regions to control siRNA production and non-CG methylation. Most NDX binding sites coincide with pericentromeric het-siRNA loci that mediate transposon silencing, and are antagonistic with R-loop structures that are prevalent in euchromatic chromosomal arms.
View Article and Find Full Text PDFArticle Synopsis
- Scientists studied how R-loops (which are like a mix of DNA and RNA) affect chromosomes and diseases.
- They focused on improving a method called DRIP to measure these R-loops better, but found some problems and errors in the original way it was done.
- After testing different techniques, they created a new, better method that helps scientists accurately find and study R-loops without mixing up the results.