Publications by authors named "Agnes Meczker"
Article Synopsis
- Acute pancreatitis (AP) is primarily characterized by severe abdominal pain, which is crucial for diagnosis, prompting a study on its characteristics among 1435 adult patients from 2012 to 2017.
- A vast majority (97.3%) reported pain on admission, predominantly intense (70%), cramping (61%), and often starting within 24 hours prior. Notably, 50.9% experienced atypical pain despite common expectations for epigastric pain.
- The study underscores the need for thorough patient assessments regarding pain type to inform monitoring and management, especially for patients with sharp and intense pain, which correlates with more severe cases and higher mortality rates.
Article Synopsis
- Pancreatic pseudocysts and walled-off necrosis can be treated through endoscopic, percutaneous, or surgical methods, but their effectiveness varies.
- A literature review showed that endoscopic drainage (ED) generally leads to better clinical success and lower recurrence rates compared to percutaneous drainage (PD) and has shorter hospital stays than surgery.
- However, ED has a lower overall clinical success rate and higher recurrence compared to surgical methods, while PD shows the lowest success and highest recurrence, making both endoscopy and surgery the more favorable options over PD.
Objectives: This study aimed to compare the clinical course of 5-aminosalicylic acid-derived, drug-induced acute pancreatitis (5-ASA-DIAP) to acute pancreatitis (AP) caused by other etiologies.
Methods: A cohort of patients with 5-ASA-DIAP was established through literature search. As a control AP (CAP) group, a cohort was generated from a registry.
Article Synopsis
- Obesity rates have risen sharply, leading researchers to study how body-mass index (BMI) impacts the severity and mortality of acute pancreatitis (AP) cases.* -
- A meta-analysis of 19 studies involving 9997 patients found that a higher BMI (over 25) significantly increases the risk of severe AP, with an odds ratio of 2.87.* -
- The study also revealed that both underweight (BMI < 18.5) and obese subgroups have higher mortality rates in AP patients, highlighting that these extremes are linked to nearly double the risk of death compared to those with normal BMI.*
5-ASA induces mild acute pancreatitis. Case report and review of the literature.
J Gastrointestin Liver Dis
June 2018
5-aminosalicylic acid has been reported to be able of inducing acute pancreatitis as an adverse reaction. However, in most case reports, rechallenge of the drug is missing; therefore, evidence is still needed to confirm its role in the clinical course of acute pancreatitis and its influence on the outcome. Here, we report a case of recurrent acute pancreatitis secondary to 5-aminosalicylic acid, with positive unintentional rechallenge.
View Article and Find Full Text PDFAim: To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.
Methods: A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the random-effects method of DerSimonian and Laird.
Although several antibodies are available for immunohistochemical detection of Ki-67, even the most commonly used MIB-1 has not been validated yet. Our aim was to compare 5 commercially available antibodies for detection of Ki-67 in terms of agreement and their ability in predicting prognosis of breast cancer. Tissue microarrays were constructed from 378 breast cancer patients' representative formalin-fixed, paraffin-embedded tumor blocks.
View Article and Find Full Text PDFCapsaicin-sensitive afferentation represents an indifferent defensive pathway from eradication in patients with H. pylori gastritis.
World J Gastrointest Pharmacol Ther
October 2011
Aim: To study the role of capsaicin-sensitive afferent nerves in Helicobacter pylori (H. pylori) positive chronic gastritis before and after eradication.
Methods: Gastric biopsy samples were obtained from corpus and antrum mucosa of 20 healthy human subjects and 18 patients with H.
Intraperitoneal surgical mesh implantation is required for laparoscopic ventral hernia repair. Composite meshes are well known in animal models and human practice. The aim of our study is to compare the biological behaviour of two different textured silicone-covered polypropylene meshes.
View Article and Find Full Text PDFIntroduction/aim: Laparoscopic ventral hernia repair requires a surgical mesh implanted in intraperitoneal position. The combined, double layer meshes are promising in animal models as well as in human practice. The aim of this study was to compare the biological behaviour of two different textured silicone covered polypropylene mesh.
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