Small volume resuscitation with 20% albumin in intensive care: physiological effects : The SWIPE randomised clinical trial.

Purpose: We set out to assess the resuscitation fluid requirements and physiological and clinical responses of intensive care unit (ICU) patients resuscitated with 20% albumin versus 4-5% albumin.

Methods: We performed a randomised controlled trial in 321 adult patients requiring fluid resuscitation within 48 h of admission to three ICUs in Australia and the UK.

Results: The cumulative volume of resuscitation fluid at 48 h (primary outcome) was lower in the 20% albumin group than in the 4-5% albumin group [median difference - 600 ml, 95% confidence interval (CI) - 800 to - 400; P < 0.

Pharmacodynamics of intravenous frusemide bolus in critically ill patients.

Objective: To assess the physiological, biochemical and haemodynamic response to a single intravenous (IV) dose of frusemide in critically patients.

Design, Setting And Patients: A prospective observational study of 21 critically ill patients in a tertiary intensive care unit in Australia.

Interventions: We collected information on urine output (UO), fluid balance, serum and urinary electrolyte levels, serum biochemical levels and haemodynamics.

Differential risk for early breastfeeding jaundice in a multi-ethnic Asian cohort.

Introduction: To explore the relationship between ethnic origin and mode of feeding with early neonatal jaundice, we examined maternal and neonatal risk factors for hyperbilirubinaemia in a multi-ethnic Asian cohort of healthy term newborns.

Materials And Methods: This is an observational cohort study in a maternity ward serving a multi-ethnic cosmopolitan community. The relationship between hyperbilirubinaemia (bilirubin >or=150 mmol/L before 48 hours to 72 hours after birth), ethnic origin, weight loss after birth, need for phototherapy, and other factors were examined.