Dissociation and re-association studies on the interaction domains of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, provide evidence for heterodimer formation.

Activation of the lectin pathway of complement begins with the activation of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, which are bound to the recognition molecules, MBL and ficolins. MASPs are Ca(2+)-dependent dimers. Dimerization and Ca(2+)-dependent association with the recognition molecules occurs via the first 3 domains, the CUB1-EGF-CUB2 region.

Age-dependent normative values for differential luminance sensitivity in automated static perimetry using the Octopus 101.

Purpose: To determine age-dependent normative differential threshold values for the Octopus 101 instrument and to create a smooth mathematical model characterizing the age-dependency and asymmetry of the hill of vision.

Methods: Static automated perimetry within the central 30 degrees visual field (VF) was conducted with the Octopus 101 (background luminance 10 cd/m(2)) in 81 eyes of 81 ophthalmologically healthy subjects (11-12 per decade of age) aged 10-79 years. A 4-2-2 staircase strategy with three reversals was run.

The normal age-corrected and reaction time-corrected isopter derived by semi-automated kinetic perimetry.

Purpose: To determine the increase in isopter extent, resulting from the measurement of, and correction for, individual reaction time (RT; the latency between stimulus presentation and individual patient response), derived under the standardized conditions of semi-automated kinetic perimetry (SKP), and to model the age- and RT-corrected normative isopter values for SKP applicable to any Goldmann stimulus combination.

Design: Cross-sectional observational study.

Participants: Eighty-three healthy participants aged 10 to 80 years (11-12 participants per decade of age).