Assessing treatment barriers in young adults with type 1 diabetes.

Aims: The current study was designed to identify barriers that prevent young adults with DM1 from achieving glycemic control.

Methods: Eighty-three young adult patients with DM1 [age 22.2 ± 2.

Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits.

The GTPase dynamin, a key player in endocytic membrane fission, interacts with numerous proteins that regulate actin dynamics and generate/sense membrane curvature. To determine the functional relationship between these proteins and dynamin, we have analyzed endocytic intermediates that accumulate in cells that lack dynamin (derived from dynamin 1 and 2 double conditional knockout mice). In these cells, actin-nucleating proteins, actin, and BAR domain proteins accumulate at the base of arrested endocytic clathrin-coated pits, where they support the growth of dynamic long tubular necks.

Glycemic control over 3 years in a young adult clinic for patients with type 1 diabetes.

Objective: To evaluate the effect of specialized young adult diabetes clinic (YAC) on glycemic control in a young adult patients with type 1 diabetes (DM1) transitioning from pediatric to adult diabetes care.

Research Design And Methods: HbA1c was retrospectively analyzed through 3 years in 15-25 y/o DM1 patients entering a YAC, and compared to similar patients entering general endocrine clinics (GEC) in a university diabetes center.

Results: Ninety-six patients were seen in the YAC, compared to 153 patients in the GEC.