Niosomal entrapment improved the bactericidal properties of azithromycin against methicillin-resistant .

This study seeks to optimize niosomal formulations of azithromycin (AZ) and evaluate their activities against methicillin-resistant (MRSA). The thin-film hydration was used to prepare niosomes containing various molar ratios of span 60, cholesterol, dicetylphosphate and AZ. Formulation 5, with 5:1:1:1 molar ratio, was optimized based on entrapment efficiency.