Publications by authors named "Agnes Carolin"
Article Synopsis
- SARS-CoV-2, responsible for COVID-19, can cause severe disease characterized by inflammatory responses like cytokine storms, but many infections are mild or asymptomatic.
- Researchers conducted RNA-Seq and histological analyses on mouse lungs infected with the omicron BA.1 variant, finding that while robust infection occurred initially, the virus was mostly cleared by day 10 post-infection.
- Acute inflammatory responses showed notably different cytokine patterns compared to severe cases, with an increase in anti-inflammatory cell types and a trend towards recovery, indicating that the immune response could foster "protective inflammation" leading to recovery without severe sequelae.
Introduction: The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated by a range of comorbidities. A considerable literature suggests iron deficiency and iron overload may contribute to increased infection, inflammation and disease severity, although direct causal relationships have been difficult to establish.
Methods: Here we generate iron deficient and iron loaded C57BL/6 J mice by feeding standard low and high iron diets, with mice on a normal iron diet representing controls.