Publications by authors named "Agnes C Kant"
The risk of miscarriage after COVID-19 vaccination before and during pregnancy.
Pharmacoepidemiol Drug Saf
January 2024
Purpose: Pregnant women are at higher risk of severe illness and adverse pregnancy outcomes due to a SARS-CoV-2 infection, which can be prevented by vaccination. Observational studies are needed to ascertain the safety of COVID-19 vaccination during pregnancy. We aimed to determine whether COVID-19 vaccination before and during pregnancy is associated with the risk of miscarriage.
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- - This study investigates the potential risk of major congenital anomalies in babies born to mothers who received a COVID-19 vaccine during the first trimester of pregnancy.
- - An analysis of data from 3,721 participants showed a similar low occurrence of congenital anomalies (1.1% for vaccinated mothers vs. 1.2% for unvaccinated), suggesting no significant association between vaccination and risk.
- - The results indicate that maternal COVID-19 vaccination in the early stage of pregnancy does not appear to increase the risk of major congenital anomalies, supporting the safety of COVID-19 vaccinations during this period.
After media attention on the possible risks of thromboembolic complications associated with the use of cyproterone/ethinylestradiol (Diane-35 and generics), the Netherlands Pharmacovigilance Centre Lareb received a large number of reports over a short period of time. We describe in detail the reports of serious undesirable effects, also taking into account the indication, time to onset and risk factors, identification of the complication, treatment and course. The reports Lareb received give an insight into the nature and impact of the occurrence of these adverse drug reactions in daily practice.
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- The study reviewed AEFI reports for influenza vaccines from 2010-2013, identifying a total of 531 reports, primarily increasing each year, especially from vaccinees.
- 6% of the cases were serious, mainly involving hospitalization; however, most adverse effects reported were mild, like headaches and muscle pain, with serious events being rare and not directly linked to the vaccine.
- Overall, the findings suggest that influenza vaccines are safe, with the main concern being extensive limb swelling, which is treatable and usually resolves without major issues.