The current understanding of germline predisposition in non-syndromic sagittal craniosynostosis: a systematic review.

Purpose: The objective of this literature review was to provide a comprehensive and up-to-date overview of the current understanding of the genetic etiology for non-syndromic sagittal craniosynostosis.

Methods: Using the PubMed database and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), we systematically reviewed relevant records on germline genetics in children with non-syndromic sagittal craniosynostosis.

Results: Two hundred two records were identified, of which 25 were included following title and abstract screening and subsequent full-text review.