Publications by authors named "Agha Khan"

Introduction: Multidisciplinary tumour boards (MDTs) play a vital role in providing high-quality cancer care. In Pakistan's compromised healthcare system, there is a lack of tumour board establishment. To bridge this gap, we aimed to enhance medical education by exposing medical students to the processes and advantages of MDTs early in their careers through conducting a mock tumour board.

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  • An artificial neural network model was developed to predict key radiobiological parameters in head and neck squamous cell carcinoma patients undergoing radiation therapy, using factors like tumor specifics and radiation doses.
  • The study utilized two datasets containing information on 31 and 215 patients, extracting relevant data to train a single-layer neural network that predicts tumor control probability and complications.
  • The model achieved high prediction accuracy, with values around 0.89 during training, indicating its potential as a useful tool for clinical treatment planning in cancer management.
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  • Locally advanced prostate cancer can present with large pelvic lymph nodes without spread to other areas.
  • Patients can receive aggressive treatment aimed at curing the disease, using dual hormonal therapy before other treatments.
  • A case study is presented where a patient was treated with this approach and showed a good early response with tolerable side effects.
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Immunizations are an important tool to reduce the burden of vaccine preventable diseases and improve population health. High-quality immunization data is essential to inform clinical and public health interventions and respond to outbreaks of vaccine-preventable diseases. To track COVID-19 vaccines and vaccinations, CDC established an integrated network that included vaccination provider systems, health information exchange systems, immunization information systems, pharmacy and dialysis systems, vaccine ordering systems, electronic health records, and tools to support mass vaccination clinics.

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  • With cancer mortality decreasing, there's a growing focus on improving the long-term quality of life (QOL) for survivors, particularly concerning fertility preservation.
  • Concerns about infertility due to cancer and its treatments significantly affect the emotional health of patients, making it a critical issue in survivorship care.
  • The article stresses the need for multidisciplinary tumor boards to address fertility issues and highlights the importance of educating patients about their reproductive options before starting treatment.
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Radiotherapy (RT) is an important component of treatment in the management of breast cancer patients. The radiation treatment paradigm has been shifted towards hypofractionated RT. This study aims to determine the severity of acute dermatitis in patients receiving hypofractionated RT for breast cancer at a tertiary care university hospital in Pakistan.

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Next-generation sequencing (NGS) is a powerful tool for detecting and investigating viral pathogens; however, analysis and management of the enormous amounts of data generated from these technologies remains a challenge. Here, we present VPipe (the Viral NGS Analysis Pipeline and Data Management System), an automated bioinformatics pipeline optimized for whole-genome assembly of viral sequences and identification of diverse species. VPipe automates the data quality control, assembly, and contig identification steps typically performed when analyzing NGS data.

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Effective laboratory-based surveillance and public health response to bacterial meningitis depends on timely characterization of bacterial meningitis pathogens. Traditionally, characterizing bacterial meningitis pathogens such as (Nm) and (Hi) required several biochemical and molecular tests. Whole genome sequencing (WGS) has enabled the development of pipelines capable of characterizing the given pathogen with equivalent results to many of the traditional tests.

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Background: Malignant pleural mesothelioma is a rare disease with poor prognosis. Surgery is used as a radical treatment modality but the risk of local relapse is very high. Therefore, radiation therapy is used in postoperative setting to improve local control.

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Simultaneous diagnosis of renal cell carcinoma with pelvic malignancies is rare but a well-documented phenomenon. It is not uncommon to have incidental renal masses on imaging done for investigating other tumors. There are no established guidelines for the treatment of patients with dual malignancies.

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Primary spinal cord glioblastoma multiforme involving the conus medullaris is an uncommon entity with poor outcomes. An aggressive multimodality treatment approach has been used, but prognosis remains same. There are no guidelines for the treatment of patients with spinal glioblastoma multiforme (GBM).

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Chronic expanding hematoma is a rare pathology, which has not been previously described as a complication of gunshot injury with retained bullet fragments. Because of the similar characteristics of chronic expanding hematoma to malignancy, it can present a diagnostic challenge for clinicians. Imaging and biopsy evaluation is needed to reach a conclusive diagnosis and implement appropriate treatment.

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High energy consumption was the major obstacle to the widespread application of melting technology in the treatment of municipal solid waste incineration fly ash. Aiming to lower the ash-melting temperature (AMT) for energy-saving, differential scanning calorimetry, X-ray diffraction and the scanning electron microscope were used to investigate the relations between AMT and the mineral evolution. The results indicated that the change of AMT was determined by the types and the contents of mineral crystals.

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Background: Energy drink is a type of beverage which contains stimulant drugs chiefly caffeine and marketed as mental and physical stimulator. Coffee, tea, soft drinks and other caffeinated beverages are not considered as energy drinks. Purpose of our study was to evaluate the awareness of medical students regarding energy drinks and their pattern and reason of energy drinks consumption.

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c-Met is a receptor tyrosine kinase that encodes protein such as hepatocyte growth factor receptor (HGFR). Inappropriate activity of c-Met can cause wide variety of carcinomas. c-Met inhibitor are relatively new class of small molecules that inhibit the enzymatic activity of c-Met tyrosine kinase.

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The Centers for Disease Control and Prevention (CDC) is looking for improved ways to collect complex, and highly sensitive, public health surveillance data. The Sexually Transmitted Diseases - Laboratory Test Methods Survey (STD-LMS) was developed to replace the traditional STD mail survey. The web-based STD-LMS offered distinct advantages over the traditional mail survey technique including,reduced time and cost of conducting the survey and avoiding the often error prone and tedious task of data entry.

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The authors describe a pilot project to standardize local laboratory data at five Indian Health Service (IHS) medical facilities by mapping laboratory test names to Logical Observation Identifier Names and Codes (LOINC). An automated mapping tool was developed to assign LOINC codes. At these sites, they were able to map from 63% to 76% of the local active laboratory tests to LOINC using the mapping tool.

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We describe a pilot project to standardize local laboratory test names to Logical Observation Identifier Names and Codes (LOINC) at five Indian Health Service (IHS) medical facilities. An automated mapping tool was developed to assign LOINC codes. The laboratory test names not mapped to LOINC by the mapping tool were assigned LOINC codes manually.

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