eNOS gene variants and the risk of premature myocardial infarction.

Background: Endothelial nitric oxide synthase (eNOS) as well as nitric oxide play an important role in the regulation of cardiovascular function. There are limited and controversial data regarding the impact of polymorphisms of eNOS gene that is implicated in the vasoconstrictive properties of the endothelium in the pathogenesis of premature myocardial infarction (MI).

Objective: We examined whether two common polymorphisms of eNOS gene (G894T and T786C) are associated with the development of premature MI.