Hypertension study in anaesthetized rabbits: protocol proposal for AT1 antagonists screening.

Introduction: The aim of this study was to establish an optimized fast and safe protocol for the pharmacological screening of AT(1) antagonists.

Materials And Methods: The pharmaceutical prototype AT(1) antagonist losartan, its active metabolite EXP3174 and the synthetic compound MMK1 were analysed in order to validate the protocol. Ang II was continuously infused while the animals received the drugs in two procedures.