Publications by authors named "Agbolahan A Sofela"
Article Synopsis
- * This study identifies the overexpression of TAM receptors (TYRO3, AXL, MERTK) and the ligand GAS6 in tumor cells from patients, revealing new interactions between these receptors in meningioma and schwannoma tissues.
- * Researchers found that inhibiting MERTK with UNC2025 and AXL with BGB324 reduced cell growth and survival in vitro, with UNC2025 proving more effective and also depleting tumor-associated macrophages in both tumor types.
Introduction: There are a number of prognostic markers (methylation, CDKN2A/B) described to be useful for the stratification of meningiomas. However, there are currently no clinically validated biomarkers for the preoperative prediction of meningioma grade, which is determined by the histological analysis of tissue obtained from surgery. Accurate preoperative biomarkers would inform the pre-surgical assessment of these tumours, their grade and prognosis and refine the decision-making process for treatment.
View Article and Find Full Text PDFThere is an unmet need for the identification of biomarkers to aid in the diagnosis, clinical management, prognosis and follow-up of meningiomas. There is currently no consensus on the optimum management of WHO grade II meningiomas. In this study, we identified the calcium binding extracellular matrix glycoprotein, Fibulin-2, via mass-spectrometry-based proteomics, assessed its expression in grade I and II meningiomas and explored its potential as a grade II biomarker.
View Article and Find Full Text PDFBackground: Craniopharyngiomas are successfully managed with surgery and/or adjuvant chemoradiotherapy but have been documented to undergo malignant transformation (MT), albeit very rarely, with only 23 reported cases. The exact cause and pathogenesis of this MT are unknown, although the literature has suggested a possible correlation with radiotherapy.
Objective: To review the reported cases of malignancy, in particular looking at the incidence, tumor characteristics, previous treatment modalities, and median survival.
Objectives: To evaluate patient and staff satisfaction with day of admission surgery in a neurosurgical unit and its effect on theatre start times.
Methods And Design: Patients were admitted to a Neurosciences admission lounge (NAL) for neurosurgery on the morning of their operation if deemed appropriate by their neurosurgical consultant. All patients in the NAL were asked to complete patient satisfaction questionnaires.