Publications by authors named "Agathe Crouzet"
Background: Cervical cancers are mainly caused by an oncogenic HPV. For locally advanced stages, the standard treatment is radio-chemotherapy (RTCT) followed by brachytherapy. Nevertheless, the prognosis remains highly heterogeneous between patients.
View Article and Find Full Text PDFRisk-reducing salpingo-oophorectomy is the gold standard for the prophylaxis of ovarian cancer in high-risk women. Due to significant adverse effects, 20-30% of women delay or refuse early oophorectomy. This prospective pilot study (NCT01608074) aimed to assess the efficacy of radical fimbriectomy followed by a delayed oophorectomy in preventing ovarian and pelvic invasive cancer (the primary endpoint) and to evaluate the safety of both procedures.
View Article and Find Full Text PDFArticle Synopsis
- The study explores the effects of locoregional treatments (LRT) like exclusive radiotherapy (ERT), surgery, and a combination of both on overall survival (OS) for patients with de novo metastatic breast cancer (dnMBC).
- It analyzed 4,507 dnMBC patients from 2008 to 2014, focusing on those who had systemic therapy and were alive at least one year post-diagnosis, finding that both ERT and bimodality therapy (BMT) significantly improved OS compared to no LRT.
- The findings suggest that while ERT and BMT were associated with better outcomes, the limitations of observational studies mean that actual benefits might still include unaccounted biases.
Introduction: Improvement in overall survival (OS) by locoregional treatment (LRT) of the primary tumor in de novo metastatic breast cancer (MBC) patients remains controversial.
Objective: The aim of our study was to evaluate the impact of LRT on OS in a large retrospective cohort of de novo MBC patients, with regard to immunohistochemical characteristics and pattern of metastatic dissemination.
Methods: We conducted a multicentric retrospective study of patients diagnosed with de novo MBC selected from the French Epidemiological Strategy and Medical Economics MBC database (NCT03275311) between 2008 and 2014.