γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection.

African trypanosomes colonise the skin to ensure parasite transmission. However, how the skin responds to trypanosome infection remains unresolved. Here, we investigate the local immune response of the skin in a murine model of infection using spatial and single cell transcriptomics.

Modelling host- interactions using human induced pluripotent stem cell-derived cortical brain organoids.

Sleeping sickness is caused by the extracellular parasite and is associated with neuroinflammation and neuropsychiatric disorders, including disruption of sleep/wake patterns, and is now recognised as a circadian disorder. Sleeping sickness is traditionally studied using murine models of infection due to the lack of alternative systems that fully recapitulate the cellular diversity and functionality of the human brain. The aim of this study is to develop a much-needed system that reduces and replaces live animals for the study of infections in the central nervous system, using sleeping sickness as a model infection.

Nasopharyngeal carriage and antimicrobial susceptibility profile of among patients infected with HIV in Jakarta, Indonesia.

In this study, the prevalence of nasopharyngeal carriage and the antimicrobial susceptibility profile of were investigated in children and adults with HIV infection in Jakarta, Indonesia. Thirty-four isolates were identified in the children (=16/90; 18%) and adults (=18/200; 9%) infected with HIV. All isolates were nontypeable and were less susceptible to ampicillin (62%) and trimethoprim/sulfamethoxazole (41%).