Health workers' perspectives of a mobile health tool to improve diagnosis and management of paediatric acute respiratory illnesses in Uganda: a qualitative study.

Objectives: Mobile health tools have potential to improve the diagnosis and management of acute lower respiratory illnesses (ALRI), a leading cause of paediatric mortality worldwide. The objectives were to evaluate health workers' perceptions of acceptability, usability and feasibility of Acute Lower Respiratory Illness Treatment and Evaluation (ALRITE), a novel mobile health tool to help frontline health workers diagnose, treat and provide education about ALRI in children <5 years.

Design: A qualitative study including semistructured interviews with health facility administrators and focus groups with primary care health workers.

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.

is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus PS2APP mice lacking (PS2APP;Trem2) at ages ranging from 4 to 22 months. Microgliosis was impaired in PS2APP;Trem2 mice, with -deficient microglia showing compromised expression of proliferation/Wnt-related genes and marked accumulation of ApoE.