Publications by authors named "Agata Sojecki"
Objective: To study the effect of human embryo multinucleation on the rate of aneuploidy, in vitro developmental morphokinetics, and pregnancy outcome.
Design: Retrospective study.
Setting: University-affiliated fertility center.
Study Question: What are the medical, psychosocial and legal aspects of gestational surrogacy (GS), including pregnancy outcomes and complications, in a large series?
Summary Answer: Meticulous multidisciplinary teamwork, involving medical, legal and psychosocial input for both the intended parent(s) (IP) and the gestational carrier (GC), is critical to achieve a successful GS program.
What Is Known Already: Small case series have described pregnancy rates of 17-50% for GS. There are no large case series and the medical, legal and psychological aspects of GS have not been addressed in most of these studies.
Article Synopsis
- A study was conducted to compare the effectiveness of minimum-dose (MS) versus high-dose (HS) stimulation protocols in improving clinical pregnancy rates for women with poor ovarian reserve (POR) undergoing IVF.
- The MS protocol involved lower doses of medications (letrozole and gonadotropins) and yielded significantly higher clinical pregnancy and live birth rates compared to the HS protocol, which used larger doses of gonadotropins.
- The findings suggest that the MS protocol is not only more effective but also more cost-efficient for treating patients with poor ovarian reserve.
Objective: To evaluate whether zona pellucida thickness (ZPT) of human embryos is correlated with maternal age, patient's hormonal status, embryo quality, and IVF outcomes.
Design: Prospective study.
Setting: University-affiliated IVF clinic.
The objective of this prospective randomized double-blind clinical trial was to evaluate whether laser zona pellucida thinning of human embryos improves clinical outcomes in women
Background: The purpose of this study was to investigate the fertilization rate and developmental potential of human oocytes in relation to the duration of their metaphase II (MII) arrest stage following the extrusion of the first polar body (1PB).
Methods: Immature metaphase I oocytes (MI; study oocytes, n = 468) that underwent meiotic maturation during brief in vitro culture and their matured in vivo, MII siblings (control oocytes, n = 3293) were subjected to ICSI. Fertilization and early cleavage were evaluated in both study and control groups.
Background: The study aim was to investigate the presence and localization of Ca2+-binding proteins and Ca2+-release receptor channels in human maturing oocytes, pronuclear zygotes and preimplantation embryos.
Methods: Immunocytochemical analysis, using specific antibodies against the proteins being studied, followed with confocal laser microscopy, was performed on human oocytes and embryos.
Results: Calreticulin and calsequestrin (the two major calcium storage proteins of somatic cells), two types of calcium release receptors, the inositol trisphosphate and ryanodine receptors (InsP(3)R-2, RyRs-1,2,3), and the molecular chaperone, calnexin, were identified in all investigated cell types.
Background: Giant binuclear oocytes occur with considerable frequency in human ovaries, but their ultimate fate remains unknown. We report the morphology, cytogenetics and developmental potential of human giant oocytes from patients undergoing assisted reproductive technologies.
Methods And Results: A total of 44 giant oocytes was collected from patients aged 22-44 years old, with an overall frequency of 0.