Publications by authors named "Agata Rossi"
Article Synopsis
- Oropouche virus (OROV) is an arbovirus that has spread beyond its usual Amazon basin habitat, with a significant outbreak occurring in the Brazilian Amazon during 2023-24, leading to cases in other Latin American countries.
- A genomic and epidemiological study from January 2023 to July 2024 showed a higher incidence of OROV in smaller municipalities, and a correlation between agricultural area sizes, particularly banana and cassava plantations, and the number of OROV cases.
- Phylogenetic analysis indicated multiple exportation events of a new reassortant lineage of OROV from Amazon regions to other parts of Brazil occurred between January and March 2024.
The Brazilian western Amazon is experiencing its largest laboratory-confirmed Oropouche virus (OROV) outbreak, with more than 6,300 reported cases between 2022 and 2024. In this study, we sequenced and analyzed 382 OROV genomes from human samples collected in Amazonas, Acre, Rondônia and Roraima states, between August 2022 and February 2024, to uncover the origin and genetic evolution of OROV in the current outbreak. Genomic analyses revealed that the upsurge of OROV cases in the Brazilian Amazon coincides with spread of a novel reassortant lineage containing the M segment of viruses detected in the eastern Amazon region (2009-2018) and the L and S segments of viruses detected in Peru, Colombia and Ecuador (2008-2021).
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