Publications by authors named "Agata Kazmierczak"

Psoriasis is a chronic, recurrent, inflammatory, and proliferative skin disease. Its etiology has not yet been fully assessed, but undoubtedly it is a multifaceted disease. The key role in its pathomechanism is played by genetic, immunologic, and environmental factors and stress.

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Article Synopsis
  • Psoriasis is an autoimmune skin condition that can cause discomfort and social withdrawal, and is treated with various therapies, including adalimumab, an anti-TNF antibody introduced in 2008.
  • The research involved testing adalimumab on normal human dermal fibroblasts to study its effects on caspase genes and regulatory micro-RNAs over different time intervals, followed by ex-vivo studies on psoriatic patients' blood.
  • Results showed that adalimumab changed the activity of caspase-related genes and micro-RNAs in vitro, but did not significantly alter the expression of caspase-6 in patients’ blood after treatment.
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The rapid progress of genetic engineering furthermore opens up new prospects in the therapy of this difficult-to-treat disease. IL-23 inhibitors, phosphodiesterase 4 (PDE4) inhibitors, and Janus kinase (JAK) inhibitors are currently encouraging further research. Two drugs which are IL-23 inhibitors are now in phase III of clinical trials.

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Introduction: Pain in the lumbosacral spine is currently one of the most common pain complaints among the elderly. About 72% of the Polish population younger than 40 years have at least once been treated by a doctor for back pain. Degenerative changes of intervertebral joints, overloads, intervertebral disc diseases, and dysfunction of spinal ligaments are very often responsible for the formation of back pain, which is basically a problem of the elderly,

Material And Methods: The study was conducted among 60 residents of a Nursing Home in Szczecin with chronic lumbar pain.

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