Successful treatment of HIV-associated multicentric Castleman's disease and multiple organ failure with rituximab and supportive care: a case report.

Introduction: Multicentric Castleman's Disease (MCD), a lymphoproliferative disorder associated with Human Herpes Virus-8 (HHV-8) infection, is increasing in incidence amongst HIV patients. This condition is associated with lymphadenopathy, polyclonal gammopathy, hepato-splenomegaly and systemic symptoms. A number of small studies have demonstrated the efficacy of the anti-CD20 monoclonal antibody, rituximab, in treating this condition.

Orbital cysticercosis: clinical manifestations, diagnosis, management, and outcome.

Purpose: To describe the clinical manifestations, diagnosis, management, and outcome of orbital cysticercosis in a tertiary eye care center in Southern India.

Design: Retrospective observational case series.

Participants: A total of 171 patients with orbital cysticercosis.

Results of laparoscopic cholecystectomy without energized dissection: a prospective study.

Introduction: Laparoscopic cholecystectomy (LC) a gold standard treatment of symptomatic gall stone disease has yet to become as safe as open cholecystectomy. The concerns of safety for both surgeon as well as patient are present even after the passage of "learning curve" phase. Emphasis on experience and technique have helped but for the morbidity associated with the use of energy sources.

Traditional polypropylene and lightweight meshes in totally extraperitoneal inguinal herniorrhaphy.

Background: Placement of a prosthetic mesh is integral to successful totally extraperitoneal (TEP) herniorrhaphy. Available meshes have supported the surgical efforts well but search for an ideal mesh continues. Post-herniorrhaphy pain is an index of patient reported outcomes (PRO).

Continuous renal replacement therapy (CRRT) in patients with liver disease: is circuit life different?

Background/aims: Clotting of haemofiltration circuits is a major complication of continuous renal replacement therapies (CRRT), yet systemic anticoagulation risks haemorrhage. Traditionally, patients with liver failure are managed with no or minimal anticoagulation, because of abnormal clotting tests and the perceived, increased bleeding risk.

Methods: We retrospectively reviewed CRRT circuit life in 50 patients; 3 groups of liver failure patients treated with CRRT (acute liver failure (ALF), acute on chronic liver disease (ACLD) and post-elective liver transplantation (LTx)), with two control groups; systemic sepsis (SS) and haematological malignancy (Haem).

Hysteroscopy in postmenopausal bleeding.

Objectives: 1) To study the etiology of postmenopausal bleeding (PMB). 2) To study the significance of hysteroscopy in evaluation of the etiopathogenic factors. 3) Correlating the diagnosis after transvaginal sonography (TVS), hysteroscopy and histopathologic diagnosis.

Endoscopic varicocelectomy by extraperitoneal route: a novel technique.

Background: Varicocelectomy for male infertility has been performed laparoscopically by transabdominal preperitoneal (TAPP) approach. Laparoscopic varicocelectomy (LV) has a potential risk of intraperitoneal injuries. LV fails to tackle the possible collateral veins in inguinal canal below the deep inguinal ring.

Diagnostic value of EUS-FNA in patients suspected of having pancreatic cancer with a focal lesion on CT scan/MRI but without obstructive jaundice.

Objective: Patients frequently present with suspected pancreatic neoplasm based on a focal pancreatic lesion on computed tomographic (CT) scan/magnetic resonance image (MRI) but without obstructive jaundice. We evaluated the performance characteristics of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in this patient subset.

Methods: This is a retrospective analysis of a prospective database and included patients who underwent EUS-FNA at a university hospital for a focal pancreatic lesion noted on CT/MRI.

EUS/EUS-FNA for suspected pancreatic cancer: influence of chronic pancreatitis and clinical presentation with or without obstructive jaundice on performance characteristics.

Background: The clinical utility of EUS-FNA is debated in patients with obstructive jaundice (ObJ) because of a very high pretest probability of pancreatobiliary malignancy (PBM) and biliary stent-induced inflammation that can potentially confound EUS-FNA diagnosis. EUS-FNA also has lower accuracy in patients with underlying chronic pancreatitis (CP).

Objective: Our purpose was to determine the clinical value of EUS-FNA for PBM diagnosis based on clinical presentation and presence of CP.

Endoscopic diagnosis and staging of mucosa-associated lymphoid tissue lymphoma.

Purpose Of Review: The role of endoscopy, including endoscopic ultrasound, in the diagnosis and management of mucosa-associated lymphoid tissue lymphomas of the stomach has evolved steadily in the last two decades. The present review summarizes recent findings and puts them in context with studies on the diagnosis and management of mucosa-associated lymphoid tissue lymphoma published earlier.

Recent Findings: Several recent studies have emphasized the crucial role of endoscopic ultrasound in treatment planning in patients with gastric mucosa-associated lymphoid tissue lymphoma.

Detorsion and conservative therapy for twisted adnexa: our experience.

Objective: 1) To determine if detorsion of the twisted adnexa is better than traditional adnexectomy to conserve the adnexa and preserve its function. 2) To determine the feasibility of detorsion in conservation of adnexa.

Design: Prospective Study from September 2004 to September 2008.

Immunostaining as an adjunct to cytology for diagnosis of pancreatic adenocarcinoma.

Background & Aims: Serial analysis of gene expression has helped identify several proteins that are expressed differentially in pancreatic cancer and are highly sensitive and specific for pancreatic adenocarcinoma. We evaluated if the diagnostic accuracy of pancreatic cancer from endoscopic ultrasound (EUS)-fine-needle aspiration (FNA) can be improved by combined evaluation of cytology and immunostaining with these markers.

Methods: This study involved the use of archived specimens from patients treated at Saint Louis University Hospital from 2002 to 2006.