[Development and implementation of a heart failure telemonitoring system: the single centre experience].

Aim      To evaluate the efficacy of remote monitoring by the compliance with body weight control and drug therapy in patients with CHF, using a specially developed software module for chronic heart failure (CHF) monitoring.Material and methods  During 2018-2020, 79 patients with dilated cardiomyopathy (mean age, 36.1 [34.

Pacemaker Implantation in Elderly Patients: Safety of Various Regimens of Anticoagulant Therapy.

Objective: To study incidence of hemorrhagic complications after pacemaker implantation in elderly patients receiving antithrombotic therapy with warfarin or uninterrupted dabigatran.

Methods: 126 patients aged 83 [82; 85] years who receive continuous antithrombotic therapy after pacemaker implantation, were enrolled in the study. Adverse event data were collected during hospitalization and further 12 weeks.

Derivation of high-purity definitive endoderm from human parthenogenetic stem cells using an in vitro analog of the primitive streak.

Human parthenogenetic stem cells (hpSCs) are pluripotent stem cells with enormous potential as cell sources for cell-based therapies: hpSCs may have histocompatibilty advantages over human embryonic stem cells (hESCs) and derivation of hpSCs does not require viable blastocyst destruction. For translation of all pluripotent stem cell-based therapies, derivation of differentiated cell products that are not contaminated with undifferentiated cells is a major technical roadblock. We report here a novel method to derive high-purity definitive endoderm (DE) from hpSCs, based on reproducing features of the normal human embryonic microenvironment.

Human parthenogenetic stem cells produce enriched populations of definitive endoderm cells after trichostatin A pretreatment.

Human parthenogenetic stem cells (hpSC) hold great promise as a source of pluripotent stem cells for cell-based transplantation therapy due to their ethical method of derivation as well as the enhanced capacity for immunomatching with significant segments of the human population. We report here the directed differentiation of hpSC to produce enriched populations of definitive endoderm. Moreover, we find that treatment of undifferentiated hpSC by trichostatin A (TSA) before applying the directed differentiation protocol significantly increases the proportion of definitive endoderm cells in the final population.

[Restoration of speech function in oncological patients with maxillary defects].

Speech quality was evaluated in 188 patients with acquired maxillary defects. Prosthetic treatment of 29 patients was preceded by pharmacopsychotherapy. Sixty three patients had lessons with a logopedist and 66 practiced self-tuition based on the specially developed test.

[Results of perftorane local use in complex treatment of patients with odontogenic phlegmons of the face and neck].

Combined treatment of 96 patients with odontogenic phlegmons of the face and neck included local application of perftorane (plasma substitute with gas transport function). The addition of perftorane to complex therapeutic measures provides significant improvement of the patients' general status and speeds up reparative processes in the wound. It facilitates secondary suturing, shortens treatment time, provides wound healing by primary intention, improves functional and cosmetic results.

[Acute musculo-articular disorders in mandibular fractures of different location and methods of their correction].

Ninety patients with acute musculo-articular disorders associated with mandibular fractures of different location were examined. Two groups of patients were distinguished, based on the presence of fragments dislocation, soft tissue injuries, and occlusion impairment: 1) 45 patients with mandibular fractures without essential dislocation of fragments and pronounced reaction of soft tissues and 2) 45 patients with notable impairment of soft tissues and dislocation of fragments. Clinical examinations and accessory diagnostic methods after removal of the splints demonstrated the relationship between the severity of musculo-articular disorders and type and location of mandibular fracture; purposeful methods of treatment have been developed.

[Role of phagocytosis activation in the mechanism of therapeutic effect of medical ozone in patients with sluggish purulent inflammations of maxillofacial soft tissues].

Sixty-three patients with local sluggish suppurative inflammations of maxillofacial soft tissues were examined. Medical ozone was added to the treatment protocols of 30 of these patients. Before treatment peripheral blood leukocyte phagocytic activity was decreased in 54 patients, which corresponded to clinical form of a sluggish inflammation.

[Ozone therapy of chronic mandibular osteomyelitis].

Clinical picture, bacterial passage, and immune status were studied in patients with chronic traumatic and chronic odontogenic mandibular osteomyelitis. The deepest disorders of biocenosis and the highest incidence of immunodeficiencies were observed in patients with chronic odontogenic osteomyelitis. Local and total ozone therapy is suggested for antibacterial and immunomodulating treatment.

[Characteristics of modern means of armament].

The manifestation of unstable modern piece is the constant local armed conflicts. Participation in this conflict requires from physicians the knowledge of modern fighting trauma and fighting pathology. New types of weapons and peculiarities of injuries they cause were the subject discussed in the last International Congresses devoted to the military medicine.

[Ozone therapy in treatment of local sluggish suppurative inflammation of maxillofacial soft tissues].

Combined local and general ozone therapy was used in 30 patients with local sluggish pyoinflammatory diseases of the maxillofacial soft tissues. The results were compared to those in 33 patients administered no ozone therapy. Ozone therapy decreased the duration of treatment more than 2-fold due to antibacterial effect and stimulation of nonspecific and immunological reactivity.

[Prevention of inflammatory complications after mandibular osteosynthesis by a combination of low-frequency ultrasound and laser exposure].

Clinical and laboratory study of the efficiency of separate and combined use of low-frequency ultrasound and laser exposure of the operative wound for prevention of pyoinflammatory complications during mandibular osteosynthesis was carried out. Clinical parameters of wound reparation in the course of healing and microbiological and cytological findings in various methods of treatment are presented. The results evidence a high efficiency of these physical methods, particularly of their combination.

[Dynamics of immune status in patients with phlegmons of the maxillofacial area during endolymphatic antibiotic therapy]].

Studies of immunotropic effects of ampicillin, gentamicin sulfate, lincomycin, and rifampicin SV used in endolymphatic therapy of patients with maxillofacial phlegmons demonstrated a pronounced immunomodulating effect of rifampicin SV in polygluquine. The immunomodulating effect of lincomycin was lower, and that of ampicillin virtually null. Gentamicin sulfate suppressed some parameters of the immune status.

[The osteoplastic efficacy of different forms of hydroxyapatite based on experimental morphological study data].

Time course of healing of induced defects in the femoral bone filled with various forms of hydroxyapatite (HA) was studied in experimental rats on days 30, 60, and 90 after inflicting the defect. HA granulate exerted the best effect on bone repair. In experiments with HA granulate, bone regenerate replaced up to one half of the area of defect by day 90.

[The use of nitatsid and gipozol'-N in the combined treatment of acute inflammatory diseases of the maxillofacial area].

Combined drugs with a hydrophilic base, nitacide and hyposol-n, were used in combined therapy of acute purulent inflammations of the maxillofacial area. Time course of clinical parameters and changes in microflora were studied in patients administered different local treatments with different inflammatory reactions. The data indicate a high efficiency of the drugs, which optimized local therapy of suppurative wounds and are recommended for wide practical use.

[A comparative evaluation of the efficacy of the isolated and joint use of dioksizol and low-frequency ultrasound in the combined treatment of phlegmons of the maxillofacial area].

The effects of dioxycol and low-frequency ultrasound alone and in combinations on the microflora of suppurative wounds formed after opening of maxillofacial phlegmons are assessed in 142 patients. Clinical and laboratory findings indicate a higher efficacy of combined use of these treatment modalities, which are recommended for optimal local treatment of purulent maxillofacial wounds.

[Relationship between nonspecific, immunologic reactivity of the body and the type of course of an acute inflammatory process].

By using the results of clinical, laboratory, and immunological studies, the authors show that the type (normoergic, hypoergic, hyperergic) of an inflammatory response is related to the parameters of nonspecific and immunological responsiveness of patients with pyo-inflammation in the maxillofacial region. The hypoergic inflammatory response is characterized by the least responsiveness mainly to its cellular link. The hyperergic inflammatory reaction is chiefly caused by considerably enhanced phagocytosis.

[Indications for the use of tactivin in the combined treatment of phlegmons of the maxillofacial area].

The effects of subcutaneous and endolymphatic tactivin (in doses of 1 ml of 0.01% solution daily for 7 days) on clinical and immunological parameters were studied in patients with acute inflammations in the maxillofacial area, running a normo-, hypo-, and hyperergic course. Tactivin accelerated the arrest of inflammatory process and improved the patients' status, particularly so in cases with the hypo- and hyperergic inflammations.