Publications by authors named "Agacdiken A"

Article Synopsis
  • Naringenin may enhance the process of browning white adipose tissue by boosting thermogenic gene expression, with a focus on liposomal formulations for better delivery.
  • The study involved two main groups of mice subjected to a high-fat diet, where one group received weekly injections of either free or liposomal naringenin to assess its effects on body weight and tissue browning.
  • Results indicated that liposomal naringenin improved gene expression related to fat browning more effectively than free naringenin, but neither formulation significantly impacted overall weight gain in the mice.
View Article and Find Full Text PDF

Nonalcoholic fatty liver disease (NAFLD) is considered one of the most important causes of chronic liver disorders in the world. Dietary pattern is a modifiable risk factor that represents the main target for the prevention and treatment of NAFLD. The aim of this cross-sectional study was to assess the impact of low-fat diet on anthropometric measurements, biochemical, and inflammatory parameters in individuals with obesity/overweight and NAFLD.

View Article and Find Full Text PDF

Introduction: Active-fixation leads have been associated with higher incidence of cardiac perforation. Large series specifically evaluating radiographic predictors of right ventricular (RV) lead perforation are lacking.

Methods: We conducted a retrospective observational study including 1691 consecutive patients implanted with an active fixation pacing and defibrillator lead at our institution between January 2015 and January 2021.

View Article and Find Full Text PDF
Article Synopsis
  • - This study investigates how prolonged fasting during Ramadan affects serum levels of the protein FGF21, which plays a role in fasting adaptation, along with nutritional status and body measurements in young adult males.
  • - Twelve healthy males aged 18-35 fasted for 16 hours daily over 29 days, with data collected on their diets, physical activity, and blood samples taken at different fasting stages.
  • - Results showed FGF21 levels rose initially during fasting but declined later, correlating with protein intake; while physical activity and energy expenditure increased, overall energy intake decreased from the start to four weeks after fasting.
View Article and Find Full Text PDF

Cardiac resynchronization therapy (CRT) device procedures have their own complications in addition to the complications associated with standard pacemaker implantations. This study aimed to analyze the predictors of the right bundle branch injury resulting in complete heart block (CHB) during right ventricular (RV) lead implantation in patients who underwent CRT with defibrillator. We conducted an observational study of consecutive 790 patients who underwent CRT with defibrillator device implantation at our institution from 2010 to 2022.

View Article and Find Full Text PDF

Background: Cardiac resynchronization therapy (CRT) is an effective option in the treatment of patients with heart failure and wide QRS. Non-alcoholic fatty liver disease (NAFLD) fibrosis score (NFS) has been shown to predict cardiac events in several patient populations. However, the relationship between NFS and response to CRT has not been investigated.

View Article and Find Full Text PDF

Background: Intraprocedural coronary angiography (CA) is recommended in patients undergoing ablation in aortic cusps to assess the relation of catheter tip and coronary ostia. In this report, we aimed to compare selective coronary angiography (SCA) through the contact force (CF)-sensing radiofrequency catheter with conventional coronary angiography (CCA) to guide ablation of premature ventricular contractions (PVC).

Methods: This was a retrospective observational cohort study of prospectively collected data of 87 consecutive patients undergoing PVC ablation at a single institution between February 2016 and June 2021.

View Article and Find Full Text PDF

Background: Extraction of the implantable cardioverter-defibrillator (ICD) leads could be a difficult procedure due to fibrous tissue around the lead and anatomical variations. In this report, we present our experience in the radiographic predictors of failure of simple manual traction (SMT) in patients with dual-coil ICD requiring lead extraction (LE).

Methods: Between January 2017 and February 2021, 103 leads were removed in 65 consecutive patients; 65 (63.

View Article and Find Full Text PDF

Introduction: Intraprocedural coronary angiography is recommeded in patients undergoing ablation in aortic cusps to assess the relation of catheter tip and coronary ostia. In this report, we present our experience in selective coronary angiography through the radiofrequency catheter during premature ventricular contraction (PVC) ablation.

Methods And Results: We prospectively recruited 43 consecutive patients who underwent PVC ablation in the aortic cusps between March 2018 and April 2021.

View Article and Find Full Text PDF
Article Synopsis
  • Cardiac resynchronization therapy (CRT) is effective for patients with severe heart failure, and this study focuses on the link between systolic aortic root motion (SARM) and CRT response.
  • Out of 56 patients with advanced heart failure monitored over 6 months, 71% showed a positive response to CRT, with SARM being identified as the sole significant predictor of this response.
  • The findings suggest that measuring SARM could help identify which patients will benefit from CRT, improving candidate selection for the therapy.
View Article and Find Full Text PDF

Background: Cardiac resynchronization therapy (CRT) has been recommended for patients with symptomatic heart failure and a wide QRS. Fragmented QRS (fQRS) on a 12-lead electrocardiography (ECG) has been shown to predict cardiac events. We aimed to investigate the relationship between resolution of fQRS and response to CRT.

View Article and Find Full Text PDF

Background: Neutrophil-to-lymphocyte (N/L) ratio has been associated with adverse outcomes in patients with acute coronary syndromes and increased risk for long-term mortality in patients with acute decompensated heart failure. We aimed to investigate the prognostic value of neutrophil-to-lymphocyte ratio on response to cardiac resynchronization therapy (CRT).

Material And Methods: Seventy consecutive patients (mean age 58 ± 13 years; 40 men) undergoing CRT were included in the study.

View Article and Find Full Text PDF

Hypertrophic cardiomyopathy (HCM) is characterized by heterogeneous clinical expression. Cardiac transplantation continues to be the gold standard for the treatment of end-stage cardiac diseases refractory to medical therapy. We presented a 27-year-old female patient with HCM who underwent successful cardiac resynchronization therapy after cardiac transplantation.

View Article and Find Full Text PDF

Purpose: Shoulder pain and disability is a common but overlooked disorder in patients with implantable cardioverter-defibrillators (ICD). We aimed to assess chronic shoulder pain and disability in patients with ICD.

Methods: Two hundred fifty-four patients (mean age, 66 ± 12 years; 156 men) with ICD were included in the study.

View Article and Find Full Text PDF

Background: Cardiac resynchronization therapy (CRT) is an effective option in the treatment of patients with heart failure (HF) and wide QRS. Fragmented QRS (fQRS) on 12-lead electrocardiography has been shown to predict cardiac events in several patient populations. However, the relationship between the number of leads with fQRS and response to CRT has not been investigated.

View Article and Find Full Text PDF

Background: The left ventricular filling pattern may show changes during respiration, which are generally used in the diagnosis of diastolic dysfunction. The clinical importance of the respiratory E/A wave pattern change has been investigated in a limited number of studies. The aim of the present study was to assess the diastolic function of hypertensive patients with respiratory changes in mitral flow over a long-term follow-up period.

View Article and Find Full Text PDF

Purpose: Cardiac resynchronization therapy (CRT) is an effective treatment for heart failure (HF) with a wide QRS. Fragmented QRS (fQRS) on a 12-lead electrocardiography (ECG) has been shown to predict cardiac events in several patient populations. We aimed to investigate the relationship between fragmented wide QRS (f-wQRS) and left ventricular dyssynchrony and response to CRT.

View Article and Find Full Text PDF

Purpose: Red blood cell distribution width (RDW) predicts adverse outcomes in patients with heart failure. We aimed to investigate the prognostic value of RDW on response to cardiac resynchronization therapy (CRT).

Methods: Sixty-six consecutive patients (mean age, 57 ± 13 years; 42 men) undergoing CRT were included in the study.

View Article and Find Full Text PDF

Background: Thromboembolic risk in permanent atrial fibrillation (AF) is strongly associated with the underlying etiology, and inflammatory parameters may contribute. The present study aimed to investigate the relationship of hs-CRP and BNP levels with left and right atrial appendage (LAA and RAA) function, presence of spontaneous echo contrast (SEC) and thrombus.

Material/methods: Eighty-four permanent AF patients with different etiologies (20 mitral stenosis, 44 hypertension and 20 hyperthyroidism) and 23 patients with sinus rhythm were included.

View Article and Find Full Text PDF

Background: Cardiac resynchronization therapy (CRT) is recommended for patients with advanced chronic heart failure. The presence of left ventricular (LV) dyssynchrony before CRT is an important predictor of response to the therapy. We aimed to investigate time course of LV dyssynchrony after CRT and the relationship between LV dyssynchrony improvement and reverse remodeling (RR).

View Article and Find Full Text PDF

Background: Heart failure patients frequently have thyroid function abnormalities. Cardiac resynchronization therapy (CRT) is a major treatment for patients with advanced chronic heart failure. We aimed to investigate the effects of CRT on thyroid functions.

View Article and Find Full Text PDF

Background: Chronic heart failure (HF) is a common, complex clinical syndrome characterized by dyspnea, fatigue and exercise intolerance. HF patients experience decreased libido and erectile dysfunction (ED). The effects of cardiac resynchronization therapy (CRT) on libido and erectile function have not been previously evaluated.

View Article and Find Full Text PDF

Background: Diabetic cardiomyopathy (DCMP) is a common complication of diabetes and is associated with increased mortality. It has been suggested that a poor R-wave progression in a resting electrocardiogram (ECG) could be a sign of cardiomyopathy.

Hypothesis: The aim of this study was primarily to analyze the relationship between poor R-wave progression and DCMP, and the effect of poor R-wave progression on cardiac functions in long-term follow-up.

View Article and Find Full Text PDF