Publications by authors named "Afzal Shakir"
Urethral strictures and bladder neck contractures (BNCs) can be significantly morbid for patients and may require intervention for effective urinary drainage. We hypothesized patients with abnormal scarring disorders, such as keloids or hypertrophic scars, are at elevated risks of urethroplasty failure as well as postprocedural urethral strictures and BNCs. We queried the TriNetX database to determine the risk of urethroplasty failure for patients with abnormal scarring disorders compared to controls.
View Article and Find Full Text PDFIntroduction: Adrenocortical carcinoma is a rare malignancy that typically presents with advanced features and carries a poor prognosis. Complete surgical resection offers patients the best survival outcomes, but this is not always achievable and many require additional therapy for advanced features. Some literature has explored the role of chemotherapy and radiation, but little has been conducted to explore the effects of multimodal therapy.
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- Mitochondrial mRNAs in Trypanosoma brucei undergo significant changes through uridylate insertions and deletions, facilitated by the RNA editing core complex (RECC) and guided by small guide RNAs (gRNAs).
- The RNA editing helicase 2-associated complex (REH2C) has been identified as an important mRNA-associated subcomplex that binds to RNA and plays a role in the editing process.
- A proposed model suggests that the assembly of editosomes involves a stepwise process where mRNP and gRNP modules dock through specific base pairing, regulated by REH2 and cofactors that help ensure the accuracy of the editing mechanism.