Publications by authors named "Afzal Khan"

Geopolymer concrete (GPC) offers a sustainable alternative by eliminating the need for cement, thereby reducing carbon dioxide emissions. Using durable concrete helps prevent the corrosion of reinforcing bars and reduces spalling caused by chemical attacks. This study investigates the impact of adding 5, 10, and 15% silica fumes (SF) on the mechanical and durability properties of GPC cured at 60 °C for 24 h.

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Background: Timely diagnosis of acute flaccid paralysis is very crucial in developing countries like Pakistan, because this will have significant impact on management.

Aim: To assess the surveillance, aetiology and epidemiology of acute flaccid paralysis in a tertiary care hospital in Peshawar, Pakistan.

Methods: This retrospective, observational study was conducted at the Paediatric Department of Lady Reading Hospital, Peshawar, in 2022.

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Objective To evaluate the appropriateness of packed red blood cell (PRBC) transfusions across different departments of a tertiary care hospital. Methods This audit included 632 patients admitted to the major departments of Hayatabad Medical Complex, Peshawar, Pakistan, who received one or more PRBC transfusions from November 2023 till July 2024. Six categories were defined who had different characteristics and thresholds for PRBC transfusion according to the Association for the Advancement of Blood & Biotherapies Red Blood Cell Transfusion International Guidelines.

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Objective: To determine the Pattern of immune reconstitution (IR) post allogeneic stem cell transplant at six months.

Study Design: Prospective observational study. Place and duration of the study: This study was conducted at The Armed Forces Bone Marrow Transplant Centre (AFMBTC) Rawalpindi, Pakistan, from May 2022 to December 2022.

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The most typical primary brain tumor, glioblastoma multiforme (GBM), has a dismal prognosis. They are removed through arduous, potentially fatal operations. The primary cause of tumor recurrence following surgery is glioblastoma stem cells (GSCs).

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Article Synopsis
  • - Asciminib is a targeted treatment for BCR::ABL1 that minimizes side effects from disrupting other kinases, with a study of 49 patients showing it is generally well tolerated over a median follow-up of 14 months.
  • - Most patients (59%) continued treatment, with only 12% stopping due to intolerance; however, treatment cessation was primarily due to intolerance rather than drug resistance (65% vs. 35%).
  • - Out of 44 patients evaluated, 66% achieved a complete cytogenetic response, with lower success rates seen in patients with specific genetic variants; further analysis indicated that the drug can influence the growth of certain resistant cancer cell populations.
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Introduction Enteric fever is prevalent in underdeveloped and developing countries. It is caused by Salmonella Typhi, which has developed resistance over the years to commonly used antimicrobials. Meropenem is an effective treatment for all complicated and uncomplicated extensively drug-resistant (XDR) bacteria, but it is administered intravenously, three times daily, by infusion, and it is quite expensive for the patient.

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In this study, PROP adsorption was investigated using activated carbon derived from Bactris Guineensis residues and physical statistical modeling. The characterization results indicate high specific surface areas (624.72 and 1125.

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  • * Out of 229 patients, the incidence of CV events was found to be 20.9%, with a notably higher occurrence in those with elevated HFA-ICOS risk scores.
  • * The findings indicate that the HFA-ICOS risk score effectively predicts the risk of developing CV and ischaemic events during nilotinib therapy, supporting its use for patient risk assessment.
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Lignites are widely available and cost-effective in many countries. Sustainable methods for their utilization drive innovation, potentially advancing environmental sustainability and resource efficiency. In the present study, FeO (∼25.

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This research study aims to understand the application of Artificial Neural Networks (ANNs) to forecast the Self-Compacting Recycled Coarse Aggregate Concrete (SCRCAC) compressive strength. From different literature, 602 available data sets from SCRCAC mix designs are collected, and the data are rearranged, reconstructed, trained and tested for the ANN model development. The models were established using seven input variables: the mass of cementitious content, water, natural coarse aggregate content, natural fine aggregate content, recycled coarse aggregate content, chemical admixture and mineral admixture used in the SCRCAC mix designs.

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Landfill leachate forms when waste-inherent water and percolated rainfall transfer are highly toxic, corrosive, acidic, and full of environmental pollutants. The release of leachate from municipal solid waste (MSW) landfill sites poses a severe hazard to human health and aquatic life. This study examined the impact of leachate from Delhi's Ghazipur landfill on the nearby groundwater quality.

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  • The study examines the likelihood of treatment-free remission (TFR) among Chronic Myeloid Leukemia (CML) patients with different chromosomal characteristics.
  • It categorizes patients into groups based on additional chromosomal abnormalities (ACA/Var-Ph group), those with only the classical Philadelphia translocation (c-Ph group), and high-risk ACA (HR-ACA subgroup) or variant Philadelphia translocations (Var-Ph subgroup).
  • Findings aim to uncover how these chromosomal variations impact the probability of achieving TFR in CML patients, which is important for treatment decisions.
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Second-generation tyrosine kinase inhibitors (2GTKI) are more effective in inducing rapid molecular responses than imatinib when used first-line in patients with chronic myeloid leukemia in chronic phase (CML-CP). However, failure of first line-2GTKI (1L-2GTKI) still occurs and there is no consensus regarding subsequent management. We retrospectively analyzed the outcome of 106 CML-CP patients treated with 1L-2GTKI and with a median follow-up of 91 months.

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This study examines the effect of Ground Granulated Blast Furnace Slag (GGBS) and steel fibers on the flexural behaviour of RC beams under monotonic loading. Various percentages of GGBS were used to substitute cement, namely 0%, 20%, 40%, 60%, and 80% and fibers were added to the concrete mix as 0%, 0.5%, 1%, and 1.

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This study, centered on the Asan Wetland in Uttarakhand, examines the ecological impact of heavy metals on aquatic insects biodiversity. It highlights the detrimental effects of metals like chromium, mercury, and lead, stemming from natural and anthropogenic sources, on aquatic insects diversity. Aquatic insects, particularly sensitive to water quality, are emphasized as key indicators of environmental health, illustrating the importance of understanding and managing the influences on wetland ecosystems.

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Metastatic dissemination following successful treatment of the primary tumour remains a common cause of death. There is mounting evidence that therapeutic interventions themselves may promote development of metastatic disease. We earlier reported that cell-free chromatin particles (cfChPs) released from dying cancer cells are potentially oncogenic.

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The field-effect transistor (FET) is a fundamental component of semiconductors and the electronic industry. High on-current and mobility with layer-dependent features are required for outstanding FET channel material. Two-dimensional materials are advantageous over bulk materials owing to their higher mobility, high ON/OFF ratio, low tunneling current, and leakage problems.

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Expression of concern for 'Influence of chemical composition on the amount of second phases precipitates and transformation temperatures of TiNiPdCu shape memory alloys prepared through novel powder metallurgy route' by Abid Hussain , RSC , 2023, , 29376-29392, https://doi.org/10.1039/D3RA05513B.

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The importance of infrared photodetectors cannot be overstated, especially in fields such as security, communication, and military. While silicon-based infrared photodetectors are widely used due to the maturity of the semiconductor industry, their band gap of 1.12 eV limits their infrared light absorption above 1100 nm, making them less effective.

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Durable concrete significantly reduces the spalling caused by chemical damage. The objective of current research is to substitute cement with supplementary such as fly ash (FA), ground granulated blast furnace slag (GGBS), and alccofine (AF). Additionally, the impact of nano-silica (NS) and silica fumes (SF) on the GPC durability when cured at various temperatures has been attempted.

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Pollution problems are increasingly becoming e a priority issue from both scientific and technological points of view. The dispersion and frequency of pollutants in the environment are on the rise, leading to the emergence have been increasing, including of a new class of contaminants that not only impact the environment but also pose risks to people's health. Therefore, developing new methods for identifying and quantifying these pollutants classified as emerging contaminants is imperative.

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Glioblastoma multiforme (GBM) is the most common and primary brain tumor with poor prognosis. They are removed by following tedious and life threatening surgeries. GBM stem cells (GSCs) are the main source of tumor recurrence after surgery.

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