Exploration and evaluation of antioxidant activity in isolated phenolics from (retz) vahl.

Given the widespread and established use of (Retz) Vahl, a member of the Oleacea family, this study aimed to identify and characterise secondary metabolites derived from the plant, with the objective of evaluating their potential biological activities. Using chromatographic separations techniques based on molecular weight and polarity, various VLC fractions of the plant were purified. These fractions yielded seven compounds- 2-(4-hydroxyphenyl)-ethanol , 2-(4-hydroxy-3-methoxy-phenyl)-ethanol , 1-(4-hydroxy-3-methoxy-phenyl)-1,2,3-propanetriol , 1-(4-hydroxy-3,5-dimethoxy-phenyl)-1,2,3-propanetriol , lupeol , β-sitosterol , and methyl linoleate , which have never been previously reported in this plant.

Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer.

Anticancer drug conjugates may benefit from simultaneous action at two targets potentially overcoming the drawbacks of current cancer treatment, such as insufficient efficacy, high toxicity, and development of resistance. Compared to a combination of two single-target drugs, they may offer an advantage of pharmacokinetic simplicity and fewer drug-drug interactions. Here, we report a series of compounds connecting tamoxifen or endoxifen with the EGFR-inhibitor gefitinib via a covalent linkage.