Post challenging serum cytokine profile (Th1 & Th2) in the vaccinated mice (Balb/C) with a new formulation of Leishmania major antigen.

Objective: The aim of this study was to carry out experiments further to our previous new formulation to modify the Leishmania major antigen that had satisfactory results previously.

Methods: In this study we made a preliminary, new vaccine with the same methodology and selected two injection doses (100&200 μg/o.1 mL), three injection Groups: Leishmania plus BCG (LB), Leishmania plus new adjuvant (Teucrium Polium) [LT], Leishmania plus BCG and Teucrium Polium (LBT), and one susceptible mouse Group (Balb/c) and measure two types of cytokines: Th1 (IFN-γ, IL-12) and Th2 (IL-4, IL-10) We prepared crude antigen combinations by five different methods using antigens from L.

Antioxidants and proinflamatory cytokines in the sera of patients with cutaneous leishmaniasis.

Background: Leishmania is a significant health problem in many parts of the world. Tumor necrosis factor (TNF) plays an essential role in Leishmania major infections.

Objective: To study the pro-inflammatory cytokines and antioxidants in four groups of cutaneous leishmaniasis patients.

Neutrophil function (innate immunity) during Ramadan.

Background: Fasting during the month of Ramadan is one of the essential religious practices of Muslims. The aim of this study was to evaluate opsonisation, phagocytosis, and nitroblue tetrazolium (NBT) reduction by white blood cells in normal, healthy, male subjects under non-fasting (before Ramadan) and fasting (after Ramadan) conditions.

Methods: In this study, 13 Muslim men, aged 28-54 years, whose health was confirmed by health application forms, gave blood samples one week before the beginning of the holy month of Ramadan and during the last week of Ramadan.

Evaluation of the effects of a new formulation of Leishmania major antigen in Balb/C and conventional white laboratory mice.

Background/purpose: Leishmaniasis is currently a threat in 80 countries around the world, and cutaneous Leishmaniasis accounts for more than 5% of new cases. It is a problematic disease in Iran, and preparing a protective vaccine has been a major goal of medical investigations. The objective of this study was to compare the protective effects of a cocktail vaccine candidate encoding various Leishmania major antigens in highly susceptible (Balb/C, or type I mice) and resistant (laboratory small white, or type II) mice.

Safety and toxicity of a new formulated Leishmania major preliminary vaccine in animal model Balb/c and small white conventional laboratory mice.

Leishmania parasites cause a spectrum of diseases that afflict the populations of 88 countries around the world and all attempts to control leishmaniasis have failed. It seems that preparing a vaccine may be the final solution. The aim of this study was to determine various Leishmania (L.