Functional Outcome of Subtrochanteric Femoral Fractures Fixation by Proximal Femoral Locking Compression Plate.

Subtrochanteric femoral fractures are one of the common fractures encountered in today's Orthopaedic practice. This area consists of mostly cortical bone with high stress generation thus heal slowly which leads implant failure. The inherent instability of this fracture and forces of the muscles with comminuted medial calcar is giving the fracture a tendency to varus collapse.

Damaged Relay Station: EEG Neurofeedback Training in Isolated Bilateral Paramedian Thalamic Infarct.

Stroke is a major public health concern and leads to significant disability. Bilateral thalamic infarcts are rare and can result in severe and chronic cognitive and behavioral disturbances-apathy, personality change, executive dysfunctions, and anterograde amnesia. There is a paucity of literature on neuropsychological rehabilitation in patients with bilateral thalamic infarcts.

Bacterial Rps3 counters oxidative and UV stress by recognizing and processing AP-sites on mRNA via a novel mechanism.

Lesions and stable secondary structures in mRNA severely impact the translation efficiency, causing ribosome stalling and collisions. Prokaryotic ribosomal proteins Rps3, Rps4 and Rps5, located in the mRNA entry tunnel, form the mRNA helicase center and unwind stable mRNA secondary structures during translation. However, the mechanism underlying the detection of lesions on translating mRNA is unclear.

Quantification of Sarcoplasmic Reticulum Ca Release in Primary Ventricular Cardiomyocytes.

In the heart, ion channels generate electrical currents that signal muscle contraction through changes in intracellular calcium concentration, i.e., [Ca].

Cognitive and Behavioral Profile of Patients with Amyotrophic Lateral Sclerosis Spectrum in the Indian Context.

Introduction: Amyotrophic lateral sclerosis (ALS) is characterized by motor, cognitive, and behavioral impairment. There is a paucity of evidence about the cognitive/behavioral features of ALS patients from India. We aimed to investigate the cognitive/behavioral profile of ALS spectrum disorders in the Indian context.

Myotonic Dystrophy Type 1 (DM1): Clinical Characteristics and Disease Progression in a Large Cohort.

Background: DM1 is a multisystem disorder caused by expansion of a CTG triplet repeat in the 3' non-coding region of DMPK. Neuropsychological consequences and sleep abnormalities are important associations in DM1.

Objective: To describe the clinical phenotype, disease progression and characterize the sleep alterations and cognitive abnormalities in a sub-set of patients.

Comprehensive Outcome Assessment and Quality of Life Following Epilepsy Surgery.

Background: Seizure freedom without deficits is the primary goal for epilepsy surgery. However, patients with medically refractory epilepsy commonly suffer from many co-morbidities related to mood, cognition, and sleep as well as social problems and resultant stigma. While epilepsy surgery literature does describe quality of life (QOL) and neuropsychological outcomes, there is a paucity of information on various common non-seizure outcomes, especially pertaining to mood, sleep, cognition, and social aspects.

Gold nanoparticles/over-oxidized poly-eriochrome black T film modified electrode for determination of arsenic.

A glassy carbon electrode, modified with gold nanoparticles/over-oxidized poly-eriochrome black T film, was fabricated for sensitive determination of As(III) by stripping voltammetry in an acidic medium. The electrode surface properties were characterized by cyclic voltammetry, electrochemical impedance spectroscopy, scanning electron microscope (SEM), and X-ray photoelectron spectroscopy (XPS). The electrode demonstrated a good response towards As(III), with a detection of 0.

Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.

ISG15 plays a crucial role in the innate immune response and has been well-studied due to its antiviral activity and regulation of signal transduction, apoptosis, and autophagy. ISG15 is a ubiquitin-like protein that is activated by an E1 enzyme (Uba7) and transferred to a cognate E2 enzyme (UBE2L6) to form a UBE2L6-ISG15 intermediate that functions with E3 ligases that catalyze conjugation of ISG15 to target proteins. Despite its biological importance, the molecular basis by which Uba7 catalyzes ISG15 activation and transfer to UBE2L6 is unknown as there is no available structure of Uba7.

Compact and Polarization Insensitive Satellite Band Perfect Metamaterial Absorber for Effective Electromagnetic Communication System.

A commercially viable metal-dielectric-metal configured triple-band metamaterial absorber is offered in this paper. It is an aggregation of four compact symmetric circles, with a swastika-shaped metal structure, which are bonded by two split-ring resonators (SRRs). Copper (annealed) of electrical conductivity 5.

Comparison Of Soft Tissue Chin And Lower Lip Thickness In Adult Patients With Various Mandibular Divergence Patterns.

Background: The influence of hard tissue discrepancies on soft tissue cannot be ignored. The divergence or angle of the mandible can influence the lower lip and chin (soft tissue), similar to the influence of incisors inclinations on the pro/ retrusion of the lips. Hence this study was carried out to find out the impact of mandibular divergence patterns on the contour and thickness of lower facial soft tissues.

An Innovative Compact Split-Ring-Resonator-Based Power Tiller Wheel-Shaped Metamaterial for Quad-Band Wireless Communication.

A split-ring resonator (SRR)-based power tiller wheel-shaped quad-band ℇ-negative metamaterial is presented in this research article. This is a new compact metamaterial with a high effective medium ratio (EMR) designed with three modified octagonal split-ring resonators (OSRRs). The electrical dimension of the proposed metamaterial (MM) unit cell is 0.

Redox oscillations destabilize and mobilize colloidal soil organic carbon.

The onset of oxic-anoxic events in soil induces biogeochemical processes that may have profound influences on the fate and transport of soil organic carbon (OC). An 18-wk long laboratory soil column study was conducted to investigate the influence of static oxic (SO), static anoxic (SA), or redox oscillation (RO) events on the release of OC. Column leachate samples were collected after 9-wk and 18-wk of incubations and separated into dissolved (<2.

Regulation of futile ligation during early steps of BER in M. tuberculosis is carried out by a β-clamp-XthA-LigA tri-component complex.

The Class-II AP-endonuclease (XthA) is a mycobacterial DNA base excision repair (BER) pathway enzyme that functions in the initial steps. It acts on DNA substrates that contain abasic sites to create nicks with 3'-hydroxyl (OH) and 5'-deoxyribose phosphate (5'-dRP) moieties. The NAD-dependent DNA ligase (LigA) is the terminal player in mycobacterial BER and seals such nicks efficiently.

Assessment of frequency, risk category and intervention needs in psychoactive drug users by using WHOASSIST Questionnaire among medical students in Karachi.

Objective: To determine the frequency of use of various psychoactive drugs among medical students in an urban setting, and to assess the risk category and intervention needs.

Methods: The descriptive cross-sectional study was conducted from January to June 2018 at four medical education institutions of Karachi; 2 each randomly selected from registered public and private sectors. From the clinical classes of each institution, fourth year was randomly chosen by lottery method.

Advanced Characterization of Ceramic State Polymer Electrolyte at Radio Frequencies.

Two newly developed non-contact dielectric measurement techniques were applied to characterize the complex permittivity spectra of a ceramic state polymer electrolyte. The Capacitance Bridge was employed to measure the electrolyte sample in a frequency range from 50 Hz to 20 KHz with a novel air gap method. The newly designed in-waveguide measurement by VNA (vector network analyzer) was applied to measure the electrolyte in the frequency range from 8.

Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2.

The SARS-CoV-2 non-structural protein 1 (Nsp1) contains an N-terminal domain and C-terminal helices connected by a short linker region. The C-terminal helices of Nsp1 (Nsp1-C-ter) from SARS-CoV-2 bind in the mRNA entry channel of the 40S ribosomal subunit and blocks mRNA entry, thereby shutting down host protein synthesis. Nsp1 suppresses host immune function and is vital for viral replication.

A New Octagonal Close Ring Resonator Based Dumbbell-Shaped Tuning Fork Perfect Metamaterial Absorber for C- and Ku-Band Applications.

In this paper, a new octagonal close ring resonator (OCRR)-based dumbbell-shaped tuning fork perfect metamaterial absorber for C- and Ku-band applications is presented. This design is a new combination of an octagonal ring close ring resonator with two dumbbell-shaped tuning forks metal strips integrated on epoxy resin dielectric substrate. The proposed perfect metamaterial absorber (PMA) is assessed by finite-integration technique (FIT)-based electromagnetic simulator-Computer simulation technology (CST) software.

The Triad of Cognition, Language, and Communication in Traumatic Brain Injury: A Correlational Study.

 Traumatic brain injury (TBI) is associated with deficits in cognition, language, and communication along with physical and psychosocial consequences. This study aimed at evaluating the association between cognition, language, and communication in a cohort of patients with TBI in southern India using standardized language specific assessment tools.  The present correlational study included 30 patients with TBI of any severity, that is, mild, moderate, and severe within the postinjury period of 6 to 36 months.

Restless legs syndrome/Willis-Ekbom disease among patients with resistant hypertension versus stroke patients-a prospective study.

Background: Epidemiological studies have shown an increased prevalence and incidence of hypertension as well as a higher incidence of stroke among patients suffering from RLS. The objective of this study was to estimate the prevalence of RLS among patients with resistant hypertension (RH) and compare the clinical characteristics of these patients with patients of stroke pre-existing RLS and with patients with primary RLS presenting to the Sleep clinic.

Methods: Consecutive patients with RH (without any identifiable cause on extensive work up) and consecutive in-patients with stroke were enrolled over a 3-year-period.

Disrupted structural connectome and neurocognitive functions in Duchenne muscular dystrophy: classifying and subtyping based on Dp140 dystrophin isoform.

Objective: Neurocognitive disabilities in Duchenne muscular dystrophy (DMD) children beginning in early childhood and distal DMD gene deletions involving disruption of Dp140 isoform are more likely to manifest significant neurocognitive impairments. MRI data analysis techniques like brain-network metrics can provide information on microstructural integrity and underlying pathophysiology.

Methods: A prospective study on 95 participants [DMD = 57, and healthy controls (HC) = 38].

Prenatal nutrition supplementation and growth biomarkers in preadolescent Bangladeshi children: A birth cohort study.

Little is known about the usefulness of biomarkers to study the influence of prenatal nutrition supplementation in improving child growth. Anthropometry is not always straightforward to understand how nutrition might impact growth, especially in settings with high rates of malnutrition and infections. We examined the effects of prenatal supplementation on growth and growth biomarkers and the relationship between anthropometric measures and growth biomarkers of children at 4.