Selenium mitigates methotrexate-induced testicular injury: Insights from male NMRI mice model.

Background And Aim: Chemotherapy, particularly with methotrexate (MTX), often elicits testicular toxicity, leading to impaired spermatogenesis and hormone imbalances. This study aimed to investigate the potential protective effects of selenium (Se) against MTX-induced testicular injury.

Materials And Methods: Male mice were divided into control, MTX, Se, and MTX + Se groups.

Effect of Cerium Oxide Nanoparticles on the Expression of Developmental and Apoptosis Genes of Testicular Tissue in 6-Day-Old NMRI Mice Fetuses.

Cerium oxide (CeO) has potential applications in medicine and various consumer products. This study investigated the effect of CeO on the expression of genes associated with apoptosis and testicular development in mouse embryos. The experimental groups of pregnant mice were injected intraperitoneally with CeO at a concentration of 10 mg/kg on days 7 and 14 of pregnancy.

The effect of different concentrations of cerium oxide during pregnancy on ovarian follicle development in neonatal mice.

Objectives: Cerium is a member of the rare metals group and widely used in drug delivery, gene therapy, molecular imaging and medicine. In this study, we investigated the effect of different doses of Cerium (IV) oxide (CeO ) during pregnancy on neonatal mice ovaries, as well as its effect on blood biochemical parameters.

Methods: Thirty pregnant NMRI mice were divided into five groups: Control and 4 groups treated with CeO (10, 25, 80, 250 mg/kg.

A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice.

Background: Both antioxidant and prooxidant activities have been previously reported for cerium oxide (CeO). The aim of this study was to investigate the effects of CeO at different doses on changes in kidney tissues and markers in neonatal mice.

Methods: We randomly divided 30 pregnant NMRI mice into five groups ( = 6 per group)-a control group and four groups treated with intraperitoneal (i.

The Effect of Cerium Oxide During Pregnancy on the Development of the Testicular Tissue of Newborn NMRI Mice.

Cerium(IV) oxide is widely used as a catalyst in all aspects of human life and human beings are exposed to these materials. The purpose of this experimental study was to investigate the effect of CeO during pregnancy on alterations in the testis tissue and blood biochemical parameters in newborn mice. Pregnant NMRI mice were divided randomly into five groups (n = 6 for each group) including one control group and 4 treatment groups.