Circumferential Eschar-Covered Necrotic Leg Ulcers in a Case of Granulomatous Vasculitis: Looking Beyond ANCA Serology.

Cutaneous vasculitis, either as a single organ or part of systemic vasculitis, can take various forms. Granulomatosis with polyangiitis (GPA) is characterized by necrotizing granulomatous inflammation in the respiratory tract and vasculitis affecting small- to medium-sized blood vessels. Skin-limited GPA, an uncommon presentation, poses diagnostic challenges and may result in delayed diagnosis.

Interaction of Heat Shock Protein 90 (HSP90), Ganetespib, and 5-Fluorouracil by Computational Approach for Colorectal Cancer Therapy.

The heat shock protein 90 kDa (HSP90) is highly conserved across diverse species, including humans, and upregulated in various cancers. As a result, it has been identified as a promising target for advancing anticancer medicine. The introduction of combinatorial chemistry in drug discovery has emphasized the need to develop new technologies in screening, designing, decoding, synthesizing, and screening combinatorial drug libraries.

Small molecular inhibitors: Therapeutic strategies for pancreatic cancer.

Pancreatic cancer (PC), a disease with high heterogeneity and a dense stromal microenvironment, presents significant challenges and a bleak prognosis. Recent breakthroughs have illuminated the crucial interplay among RAS, epidermal growth factor receptor (EGFR), and hedgehog pathways in PC progression. Small molecular inhibitors have emerged as a potential solution with their advantages of oral administration and the ability to target intracellular and extracellular sites effectively.

Efficacy and safety of diode laser for facial hair reduction in hirsutism-a clinico-trichoscopic evaluation.

Background: Hirsutism is the presence of excessive terminal hair on androgen-dependent sites of the body. Lasers like Alexandrite, diode, and Nd:Yag lasers have been used for hair reduction with varying efficacy. Trichoscopy of hair is a simple noninvasive method of hair assessment.

Quantifying the advantages and acceptability of linking dialysis machines to an electronic medical record.

Aim: To establish and quantify the time saved by redirecting nursing workload from recording and entering haemodynamic data during chronic dialysis sessions by linking dialysis machines directly to the electronic medical record.

Methods: We developed a bespoke interface from the HL7 feed from the dialysis machines (largely Fresenius 5008) to our EMR system (Cerner). We quantified the time nurses spent with the patient, computer, dialysis machine and sorting our patient related issues by observation using independent observers in a time and motion study.

Linear morphea with overlying lichen sclerosus and calcinosis cutis associated with juvenile dermatomyositis.

Juvenile dermatomyositis (JDM) is associated with many distinguishing features including cutaneous calcinosis, vasculitis, and ulcerated lesions. In this case, we describe an unusual presentation in a 12-year-old girl who had muscle weakness along with linear morphea over the right upper and lower extremities with overlying lichen sclerosus and calcinosis cutis. Of interest, these initial cutaneous manifestations occurred years before onset of myositis.

Teledermatology Services during COVID-19 Pandemic: Experience of a Tertiary Care center in Western India.

Background: Telemedicine has emerged as an important tool in providing patient care during the COVID-19 pandemic. Hence, we aimed to study the clinico-epidemiological profile of patients seen in the teledermatology outpatient department (OPD) during the COVID-19 pandemic.

Material And Methods: Retrospective data analysis of records of patients, who consulted in telemedicine OPD from 20 April 2020 to 5 Feb 2021 was done.

A comprehensive analysis of Trehalose-6-phosphate synthase (TPS) gene for salinity tolerance in chickpea (Cicer arietinum L.).

Soil salinity affects various crop cultivation but legumes are the most sensitive to salinity. Osmotic stress is the first stage of salinity stress caused by excess salts in the soil on plants which adversely affects the growth instantly. The Trehalose-6-phosphate synthase (TPS) genes play a key role in the regulation of abiotic stresses resistance from the high expression of different isoform.

Gas chromatography-mass spectrometry (GC-MS) profiling of aqueous methanol fraction of Lehm. & Lindenb. and Wilson for probable antiviral potential.

The bryophytes consist of liverworts, mosses, and hornworts, among which the liverworts are quite different in having cellular oil bodies and contain numerous terpenoids, acetogenins, quinones, phenylpropanoids, flavonoids, etc. These metabolites exhibit interesting biological activity such as allergenic response, insecticide, cytotoxic, neurotrophic, antimicrobial, and anti-HIV actions, etc. Though several bioactive compounds have been isolated in many liverworts, yet most of the liverworts have been unexplored till date regarding their phytochemistry.

Pharmacological, Cytotoxic, Immunostimulant, and Auto-Immune Activity of Thalloid Liverworts: An Overview.

Bryophytes have historically been employed as verdant medicine in China, Native America and India. Phenolics, glycosides, fatty acids, other rare aromatic compounds and Terpenoids found in bryophytes may help prevent cancer and other chronic disorders. Liverworts have historically been utilized in traditional medicine and also as immu-nomodulators or immunostimulants.

Colorectal Cancer Biology, Diagnosis, and Therapeutic Approaches.

Colorectal cancer (CRC) is the second most diagnosed disease worldwide. It is the fourth leading cause of cancer related mortalities. Higher probability for the occurrence of CRC is due to western lifestyle, age, and personal history of chronic diseases.

Optimization and Comparison of Three-Dimensional Culture Conditions in Different Media of Coculture and Encapsulation System for Follicular Development in .

The establishment of an culture system for complete oocyte maturation from the early stages of ovarian follicles is still a challenge. The aim of the present study was to assess the effect of different matrix with different culture media on the developmental growth of ovarian follicles . An ovarian histoarchitectural study was carried out to identify the primordial (0.

Synergetic Structural Transformation of Pt Electrocatalyst into Advanced 3D Architectures for Hydrogen Fuel Cells.

A new direction for developing electrocatalysts for hydrogen fuel cell systems has emerged, based on the fabrication of 3D architectures. These new architectures include extended Pt surface building blocks, the strategic use of void spaces, and deliberate network connectivity along with tortuosity, as design components. Various strategies for synthesis now enable the functional and structural engineering of these electrocatalysts with appropriate electronic, ionic, and electrochemical features.