Publications by authors named "Afrah S Sait"
Article Synopsis
- The study focused on the safety and efficacy of COVID-19 treatments (remdesivir, dexamethasone, convalescent plasma) in solid organ transplant recipients, comparing outcomes between two time periods.
- In Era 1 (March-May 2020), treatments were limited, with low usage of newer therapies, while Era 2 (June-November 2020) saw a significant increase in their application among patients.
- Outcomes showed low mortality rates (5.6%) and minimal allograft rejection (2.8%), indicating that the therapies did not harm transplant function or lead to more infections.
Background: The impacts of COVID-19 on lung allograft function, rejection, secondary infection, and clinical outcomes in lung transplant recipients (LTRs) remain unknown.
Methods: A 1:2 matched case-control study was performed to evaluate rehospitalization, lung allograft function, and secondary infections up to 90 d after COVID-19 diagnosis (or index dates for controls).
Results: Twenty-four LTRs with COVID-19 (cases) and 48 controls were identified.
Background: Human metapneumovirus (HMPVi) and parainfluenza virus (PIVi) infections are common community-acquired infections in lung transplant recipients (LTRs), but data are extremely limited.
Methods: A retrospective study including all LTRs at the Johns Hopkins Hospital during July 2010-June 2019 with positive HMPV and PIV polymerase chain reaction respiratory specimens was performed.
Results: Thirty-one HMPV- and 53 PIV-infected LTRs were identified.
Immunosuppression and comorbidities might place solid organ transplant (SOT) recipients at higher risk from COVID-19, as suggested by recent case series. We compared 45 SOT vs. 2427 non-SOT patients who were admitted with COVID-19 to our health-care system (March 1, 2020 - August 21, 2020), evaluating hospital length-of-stay and inpatient mortality using competing-risks regression.
View Article and Find Full Text PDFBackground: The coronavirus disease 2019 (COVID-19) pandemic has led to significant reductions in transplantation, motivated in part by concerns of disproportionately more severe disease among solid organ transplant (SOT) recipients. However, clinical features, outcomes, and predictors of mortality in SOT recipients are not well described.
Methods: We performed a multicenter cohort study of SOT recipients with laboratory-confirmed COVID-19.
Pitfalls and Unexpected Benefits of an Electronic Hand Hygiene Monitoring System.
Am J Infect Control
September 2019
Background: No single strategy is more effective than proper hand hygiene (HH) in reducing the spread of nosocomial infections. Unfortunately, health care worker compliance with HH is imperfect. We sought to improve HH compliance using an electronic hand hygiene monitoring system (EHHMS) in 2 units to collect unbiased data and provide feedback.
View Article and Find Full Text PDF. The etiology of the high prevalence of hypertension among patients with hemophilia (PWH) remains unknown. .
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