Publications by authors named "Afonso Dinis da Costa Passos"
Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases.
Mem Inst Oswaldo Cruz
September 2017
Background: In Brazil, few studies have investigated the prevalence of infection with the precore (PC) and basal core promoter (BCP) mutants of the hepatitis B virus (HBV).
Objectives: This study aimed to analyse the frequency of PC and BCP mutations among patients infected with HBV and to evaluate the association between the variants and advanced hepatic disease.
Methods: A total of 161 patients infected with HBV were studied.
Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration.
Braz J Infect Dis
August 2017
Article Synopsis
- The study aimed to identify and analyze the different genotypes and subgenotypes of the Hepatitis B virus (HBV) present in Southeast Brazil, comparing them with global counterparts.
- Out of 166 chronic HBV carriers, genotype D was the most common (58.4%), with subgenotype D3 found in 42.9% of the cases; genotype A was also prevalent at 36%.
- The phylogenetic analysis revealed that the HBV sequences were similar to those found in Europe, Asia, and the Middle East, suggesting historical links due to immigration patterns during colonization.
Introduction: Hepatitis C virus (HCV) is primarily transmitted via contact with the blood of infected patients, although the form of contact has not been identified for a significant percentage of carriers. The present study evaluated possible risk factors for HCV transmission in a medium-sized town located in the northwest region of the State of São Paulo.
Methods: This was a case-control study, with the case group consisting of 190 chronic HCV carriers older than 18 years residing in the municipality of Catanduva.
Clinical, demographic and epidemiological characteristics of patients with hepatitis B followed at a university hospital in southeastern Brazil: predominance of HBeAg negative cases.
Rev Soc Bras Med Trop
September 2011
Introduction: Hepatitis B is common in Brazil, although there are regional differences regarding the degree of endemicity, the most frequent forms of transmission and the presence of different evolutive stages of chronic disease. The present study aimed to determine the clinical, demographic and epidemiological characteristics of patients chronically infected with hepatitis B virus (HBV) residing in the Ribeirão Preto region, southeastern Brazil.
Methods: A total of 529 medical records of individuals with HBV monoinfection were reviewed.