Publications by authors named "Afnan Salaka"
Article Synopsis
- The study investigates the combined effects of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and vitamin D (VD) on metabolic dysfunction-associated steatohepatitis (MASH) in type 2 diabetic mice, filling a gap in previous research.
- Diabetic mice were subjected to a high-fructose/high-fat diet and then treated with either SGLT2i, VD, or both, revealing that while SGLT2i alone was effective, the combination treatment offered superior protection.
- Results showed significant improvements in metabolic parameters, liver health, and reductions in inflammation and oxidative stress markers, indicating that the combined therapy enhances hepatic protection against diabetes-induced MASH.
Background: Overweight and obesity (OO) are significant public health issues, and many elements, including genetics, epigenetics, sedentary lifestyle, comorbid conditions, psychological and environmental pressures, have been linked to OO. More than 2 billion people are presently impacted by the global obesity epidemic, which is still advancing relentlessly. It is a significant public health concern and a major contributor to healthcare costs, because it increases the chance of developing conditions such as heart disease, stroke, type 2 diabetes, and chronic kidney disease (CKD).
View Article and Find Full Text PDFBackground: Parkinson's disease has been reported in a small number of patients with chromosome 22q11.2 deletion syndrome. In this study, we screened a series of large, independent Parkinson's disease case-control studies for deletions at 22q11.
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