Encapsulated gadolinium and dysprosium ions within ultra-short carbon nanotubes for MR microscopy at 11.75 and 21.1 T.

Single-walled carbon nanotubes (SWNTs) have gained interest for their biocompatibility and multifunctional properties. Ultra-short SWNTs (US-tubes) have demonstrated high proton relaxivity when encapsulating gadolinium ions (Gd(3+)) at clinical field strengths. At higher field strengths, however, Gd(3+) ions demonstrate decreased proton relaxation properties while chemically similar dysprosium ions (Dy(3+)) improve relaxation properties.

Magnetic resonance contrast and biological effects of intracellular superparamagnetic iron oxides on human mesenchymal stem cells with long-term culture and hypoxic exposure.

Background Aims: Human mesenchymal stem cells (hMSCs) have gained interest for treatment of stroke injury. Using in vitro culture, the purpose of this study was to investigate the long-term detectability of hMSCs by magnetic resonance imaging (MRI) after transfection with a superparamagnetic iron oxide (SPIO) and evaluate the effects of SPIO on cellular activity, particularly under an ischemic environment.

Methods: hMSCs were exposed to low doses of SPIOs.

Intracellular SPIO labeling of microglia: high field considerations and limitations for MR microscopy.

The purpose of this study is to investigate MRI contrast as a function of magnetic field strength for microglia labeled with superparamagnetic iron oxide (SPIO) nanoparticles. A rat microglia cell line, Bv2, was incubated with SPIOs for 6 h. In two separate experiments conducted at 11.