Effects of oral administration of ondansetron, a 5-HT receptor antagonist, on anxiety-related behaviors and colonic hypercontractility in repeated stress-induced mice.

Purpose: Chronic psychological stress develops and exacerbates irritable bowel syndrome (IBS). 5-hydroxytryptamine (5-HT) via activation of intestinal 5-HT receptors involves impairment of intestinal functions. This study aimed to investigate the effects of ondansetron, a 5-HT receptor antagonist, on locomotor activity, anxiety-related behaviors, and colonic functions in repeated water avoidance stress.

5-HT receptors modulate changes in voiding pattern and bladder contractility in water avoidance stress-induced bladder overactivity in male mice.

Purpose: Chronic psychological stress aggravates painful bladder syndrome symptoms. Previous studies suggest roles of 5-HT receptors in regulating micturition and bladder hypersensitivity. This study aimed to investigate the roles of 5-HT receptors in modulating voiding patterns and spontaneous bladder contractile properties in water avoidance stress-induced mice.