Publications by authors named "Afet Akdag-Kose"
Article Synopsis
- * Out of 4,100 patients with Behçet's disease, only 4.7% had late-onset, with findings showing that symptoms and complications often developed later compared to adult and juvenile cases.
- * The research concluded that, despite some differences, LBD patients require similar follow-up care as those with adult and juvenile Behçet's disease due to comparable levels of systemic involvement over time.
Serum Elafin as a Potential Marker of Disease Activity in Behçet's Disease.
Indian J Dermatol
January 2023
Background: Elafin is a serine protease inhibitor with anti-inflammatory properties. It is expressed in various epithelial tissues with increased production under inflammatory conditions. Increased tissue elafin expression in Behçet's disease (BD) lesions has previously been demonstrated.
View Article and Find Full Text PDFIntroduction: Behçet's disease (BD) is a chronic inflammatory disease which can be limited to only mucocutaneous tissues or can affect different systems of the body.
Aim: To investigate the association of endothelial and erectile dysfunctions with BD, on the basis of comparative analysis between mucocutaneous and systemic BD.
Material And Methods: Thirty-eight men diagnosed with BD were included in the present study.
Innate lymphoid cells (ILCs) are lymphoid cells that have important effector and regulatory functions in innate immunity and tissue remodeling. Uncontrolled activation and proliferation of ILCs can contribute to inflammatory autoimmune diseases. Behcet's disease (BD) is a complex systemic inflammatory disorder of unknown etiology.
View Article and Find Full Text PDFBehçet's disease is a genetically complex disease of unknown etiology characterized by recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed a genome-wide association study with 311,459 SNPs in 1,215 individuals with Behçet's disease (cases) and 1,278 healthy controls from Turkey. We confirmed the known association of Behçet's disease with HLA-B*51 and identified a second, independent association within the MHC Class I region.
View Article and Find Full Text PDFDirect immunofluorescence in Behçet's disease: a controlled study with 108 cases.
Yonsei Med J
August 2009
Purpose: Behçet's disease (BD) is a disease of unknown etiology, which has multisystemic involvement. This multisystemic involvement might be the clue for an autoimmune pathogenesis. In order to evaluate an autoimmune pathogenesis, we examined immunoreactans depositions in the skin of BD patients.
View Article and Find Full Text PDFBackground: Vascular lesions can be the presenting sign of Behçet's disease (BD) preceding classical symptoms. The aim of this study was to evaluate the prevalence and types of vascular involvement in BD.
Methods: Among 2319 patients diagnosed with BD according to the criteria of the International Study Group for BD, 332 patients (279 male, 53 female) with vascular involvement were included in this study.
Background: The prevalence of Behçet's disease (BD) is much higher in countries along the ancient Silk Route, extending from Japan to Mediterranean countries including Turkey, than in northern Europe and the USA. Three previous epidemiologic surveys have been carried out in different regions of Turkey.
Patients And Methods: This study investigated the cross-sectional prevalence of BD in individuals aged > 12 years in Istanbul, Turkey, in two stages.