Publications by authors named "Afaf Titouna"
Article Synopsis
- G6PD deficiency is linked to malaria, suggesting a potential protective role against the disease despite the risk of hemolysis for carriers.
- A systematic review analyzed studies to determine the effects of G6PD deficiency on malaria and found no strong association between the deficiency and uncomplicated malaria overall, but noted significant protective effects in African populations.
- The data indicates that G6PD deficiency may primarily protect heterozygous individuals against uncomplicated malaria, with no effect observed on severe malaria cases or other malaria species.
It is essential to continue the search for novel antimalarial drugs due to the current spread of resistance against artemisinin by Plasmodium falciparum parasites. In this study, we developed in silico models to predict hemozoin inhibitors as a potential first-step screening for novel antimalarials. An in vitro colorimetric high-throughput screening assay of hemozoin formation was used to identify hemozoin inhibitors from 9,600 structurally diverse compounds.
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