Publications by authors named "Aeri Shin"
Stem Cells Transl Med
March 2024
Article Synopsis
- - Fetal spinal cord ischemia can cause serious neurological issues but studying it has been difficult due to the lack of good experimental models.
- - The researchers created necrotic core-free human spinal cord organoids (nf-hSCOs) to test drugs for their effects on this condition, finding that using smaller organoids prevented complications from necrosis.
- - While many tested chemicals didn't show significant benefits, rapamycin was identified as a mild neuroprotective agent, making nf-hSCOs a promising model for studying fetal neural ischemia and screening potential treatments.
Adv Sci (Weinh)
July 2023
Article Synopsis
- - The study explores how symmetry breaking in human pluripotent stem cells (hPSCs) can mimic the processes of axis formation and cell patterning during development.
- - Researchers created polarized spinal cord organoids (pSCOs) that exhibit organized dorsoventral (DV) structures and can differentiate into specific cell types through the application of specific signals.
- - The control of dorsal/ventral domain proportions in pSCOs is achieved by adjusting the sizes of the initial cell micropatterns, resulting in distinct neural activities in mature organoids, which sheds light on the principles of neural development.
