Publications by authors named "Aemilia R Sprouse"
J Biol Chem
November 2024
Article Synopsis
- The human IRGM gene is associated with inflammatory conditions like sepsis and Crohn's disease, where decreased expression can lead to increased inflammatory markers in the body.
- Prior research showed that changes in metabolism and mitochondrial functions are linked to increased inflammatory responses, but the exact mechanisms were unclear.
- New findings revealed that type I interferon (IFN) production in macrophages is crucial for heightened cytokine levels due to IRGM deficiency, and novel pathways affecting mitochondrial function contribute to this inflammatory response.
