Life History, Fertility, and Short-Term Mating Motivation.

The current research examines the impact of women's early-life socioeconomic status (SES; used as a proxy measure of life history strategy), relationship status, and ovulatory cycle phase on their desire for short-term mating. Results revealed that during the periovulatory phase (i.e.

Vanishing time in the pursuit of happiness.

Happiness can be conceptualized as a positive affective state or as a goal whose pursuit ironically pulls the pursuer away from achieving it (Mauss, Tamir, Anderson, & Savino in Emotion, 11(4), 807-815, 2011). But how do people think about time during this latter, never-ending pursuit of happiness? The present investigation asks how seeking happiness influences perceptions of time availability. Four studies demonstrated that trait-level happiness seeking (Study 1) as well as direct manipulation of happiness seeking (Studies 2, 3, and 4) consistently reveal the same pattern: reduced feelings of time availability while pursuing happiness.

ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex.

ATP-dependent DNA end recognition and nucleolytic processing are central functions of the Mre11/Rad50 (MR) complex in DNA double-strand break repair. However, it is still unclear how ATP binding and hydrolysis primes the MR function and regulates repair pathway choice in cells. Here,Methanococcus jannaschii MR-ATPγS-DNA structure reveals that the partly deformed DNA runs symmetrically across central groove between two ATPγS-bound Rad50 nucleotide-binding domains.

DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.

The Mre11-Rad50-Nbs1 (MRN) complex plays important roles in sensing DNA damage, as well as in resecting and tethering DNA ends, and thus participates in double-strand break repair. An earlier structure of Mre11 bound to a short duplex DNA molecule suggested that each Mre11 in a dimer recognizes one DNA duplex to bridge two DNA ends at a short distance. Here, we provide an alternative DNA recognition model based on the structures of Methanococcus jannaschii Mre11 (MjMre11) bound to longer DNA molecules, which may more accurately reflect a broken chromosome.

RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility.

BLT2, a low affinity receptor for leukotriene B4 (LTB4), is a member of the G protein-coupled receptor family and is involved in many signal transduction pathways associated with various cellular phenotypes, including chemotactic motility. However, the regulatory mechanism for BLT2 has not yet been demonstrated. To understand the regulatory mechanism of BLT2, we screened and identified the proteins that bind to BLT2.