Publications by authors named "Advaith Subramanian"
Background: It is well established that genetic factors are implicated in the development of Alzheimer's disease (AD), but there is growing interest in how environmental factors like infection contribute to its progression. Recent evidence suggests that greater exposure to infections across the lifespan can potentiate the rate and severity of cognitive decline. In addition to contributing to mechanisms underlying the aggregation of Aβ fragments and phosphorylation of tau proteins, the infectious etiology of dementia may be caused by infectious agents triggering neuroinflammatory pathways and degradation of the blood-brain barrier (BBB).
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- - The systematic review focused on the effectiveness and impacts of respiratory isolation for pulmonary tuberculosis (TB), highlighting the lack of clear guidelines on how long isolation should last and inconsistent implementation across different settings.
- - Researchers analyzed 17 studies, finding limited direct comparisons between isolation and no isolation. Some evidence suggests isolation might reduce transmission, but studies often combined it with other interventions and did not show significant effects post-treatment initiation.
- - The review revealed significant negative consequences of isolation, including impacts on employment, education, and mental health, especially in marginalized groups, indicating that public health decisions must balance community transmission risks with the personal hardships faced by individuals with TB.
Utilization of high-quality clinical practice guidelines has the potential to positively impact health outcomes. This study aimed to assess the quality and content concordance of national and international recommendations on hypertensive disorders of pregnancy (HDPs). Searches were conducted of the MEDLINE database and reference lists generated from national and international agencies.
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