A large-scale targeted proteomics of serum and tissue shows the utility of classifying high grade and low grade meningioma tumors.

Background: Meningiomas are the most prevalent primary brain tumors. Due to their increasing burden on healthcare, meningiomas have become a pivot of translational research globally. Despite many studies in the field of discovery proteomics, the identification of grade-specific markers for meningioma is still a paradox and requires thorough investigation.