Publications by authors named "Adrienn Halasz"
Pancreatic necrosis is a consistent prognostic factor in acute pancreatitis (AP). However, the clinical scores currently in use are either too complicated or require data that are unavailable on admission or lack sufficient predictive value. We therefore aimed to develop a tool to aid in necrosis prediction.
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- Chronic pancreatitis (CP) is a severe condition with no specific treatment, making early diagnosis essential for better outcomes.
- A study analyzed data from both acute pancreatitis (AP) and chronic pancreatitis (CP) patients, revealing that experiencing three or more episodes of AP significantly increases the risk of developing CP.
- Findings suggest that patients with three or more recurrent AP episodes could be classified as having early chronic pancreatitis (ECP), allowing for earlier diagnosis without extra healthcare costs.
Today, insulin hypersensitivity reactions are rare side effects of insulin therapy. In two-thirds of the suspected insulin allergy cases, the clinical symptoms are not related to insulin. The authors report the case of a 64-year-old female patient, by whom lymphocyte tarnsformation test (LTT) has been used to elucidate the background of allergic symptoms developed during insulin therapy.
View Article and Find Full Text PDFBackground: Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are contradictory. Our aim was to investigate the dose-dependent effect of hypertriglyceridemia on AP.
View Article and Find Full Text PDFIntroduction: The incidence of acute pancreatitis (AP) and the prevalence of metabolic syndrome (MetS) are growing worldwide. Several studies have confirmed that obesity (OB), hyperlipidemia (HL), or diabetes mellitus (DM) can increase severity, mortality, and complications in AP. However, there is no comprehensive information on the independent or joint effect of MetS components on the outcome of AP.
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- Researchers examined the effectiveness of C-reactive protein (CRP) and white blood cell count (WBC) in assessing acute pancreatitis (AP) through a review of existing studies and data analysis of 1435 patient episodes.
- The study found that CRP levels were not reliable indicators of mortality or severity in AP cases, with low accuracy in predictions regardless of when the levels were measured.
- However, using CRP levels within the first 24 hours after pain onset as a criterion for including patients in clinical trials significantly increased the rates of severe cases and mortality, thus potentially simplifying the patient selection process for trials.
Article Synopsis
- Unwarranted use of antibiotics in acute pancreatitis is a widespread issue, and the reasoning behind it is not well understood, prompting a study to improve prescription practices.
- The research involved systematic data collection, a global questionnaire, analysis of existing patient data, and the application of a grading system to develop evidence-based recommendations.
- Findings showed a lack of consensus on when to start antibiotics, with significant variability in usage rates, and highlighted that procalcitonin is a more reliable marker for infection than traditional indicators like WBC and CRP, leading to recommendations for reducing unnecessary antibiotic treatment.
Article Synopsis
- This study investigates the effectiveness of endoscopic retrograde cholangiopancreatography (ERCP) in treating acute biliary pancreatitis (ABP) in Hungary, highlighting the challenges of determining when to use the procedure.
- Out of 356 ABP patients, 75% underwent ERCP, but the procedure had suboptimal indicators, with biliary cannulation success rates at only 84% and higher complications in cases of unsuccessful cannulation and clearance.
- The research concludes that timely and effective ERCP is essential for better patient outcomes, as delays in performing the procedure can lead to increased local complications.
Introduction: Chronic pancreatitis is an inflammatory disease associated with structural and functional damage to the pancreas, causing pain, maldigestion and weight loss and thus worsening the quality of life.
Aims And Methods: Our aim was to find correlations from a multicentre database representing the epidemiological traits, diagnosis and treatment of the disease in Hungary. The Hungarian Pancreatic Study Group collected data prospectively from 2012 to 2014 on patients suffering from chronic pancreatitis.
Article Synopsis
- The study focused on understanding the clinical characteristics and management of acute pancreatitis (AP) in a large group of patients across multiple centers in Hungary.
- It involved collecting data on 86 clinical parameters from 600 adult patients diagnosed with AP over a two-year span, identifying that biliary and alcoholic causes were the most prevalent.
- Key findings revealed that certain factors, like hyperlipidaemia and the absence of abdominal pain, were linked to increased severity and mortality, highlighting the importance of following established guidelines to improve patient outcomes.
Objective: Biomedical investment trends in 2015 show a huge decrease of investment in gastroenterology. Since academic research usually provides the basis for industrial research and development (R&D), our aim was to understand research trends in the field of gastroenterology over the last 50 years and identify the most endangered areas.
Methods: We searched for PubMed hits for gastrointestinal (GI) diseases for the 1965-2015 period.
Background And Aims: Pancreatic cancer is a devastating disease with poor prognosis. There is very limited information available regarding the epidemiology and treatment strategies of pancreatic cancer in Central Europe. The purpose of the study was to prospectively collect and analyze data of pancreatic cancer in the Hungarian population.
View Article and Find Full Text PDFObjectives: Variant c.811+32C>A in intron 4 of the cholecystokinin-B receptor gene (CCKBR) was reported to correlate with higher pancreatic cancer risk and poorer survival. The variant was suggested to induce retention of intron 4, resulting in a new splice form with enhanced receptor activity.
View Article and Find Full Text PDFBackground: Pancreatic ductal HCO3(-) secretion is critically dependent on the cystic fibrosis transmembrane conductance regulator chloride channel (CFTR) and the solute-linked carrier 26 member 6 anion transporter (SLC26A6). Deterioration of HCO3(-) secretion is observed in chronic pancreatitis (CP), and CFTR mutations increase CP risk. Therefore, SLC26A6 is a reasonable candidate for a CP susceptibility gene, which has not been investigated in CP patients so far.
View Article and Find Full Text PDFObjectives: Serine protease inhibitor Kazal type 1 (SPINK1) provides an important line of defense against premature trypsinogen activation within the pancreas. Our aim was to identify pathogenic SPINK1 promoter variants associated with chronic pancreatitis (CP).
Methods: One hundred CP patients (cases) and 100 controls with no pancreatic disease from the Hungarian National Pancreas Registry were enrolled.
Introduction: Data on disease burden of cystic fibrosis in Hungary are scarce.
Aim: To assess quality of life and resource utilisations of patients with cystic fibrosis.
Method: In a cross-sectional survey (BURQOL-RD project), the EQ-5D-5L questionnaire was applied and healthcare utilisations were retrospectively surveyed.
Major cause of death in patients with cystic fibrosis (CF) is colonization with Staphylococcus aureus and Pseudomonas aeruginosa. The wide phenotypic variation in CF patients suggests that genes other than the cystic fibrosis transmembrane conductance regulator (CFTR) gene modify the disease. The 8.
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