Publications by authors named "Adrien Noa-Bolano"
Article Synopsis
- Acquired resistance to cisplatin, a common treatment for ovarian cancer, presents significant challenges in therapy effectiveness, leading researchers to identify a new phenomenon in cancer cell behavior.
- This study introduces the concept of epithelial-mesenchymal-ectodermal transition (EMET), which describes how ovarian cancer cells undergo a transformation that includes characteristics of neuronal differentiation and stemness, indicating a shift in their cellular identity.
- The researchers also found that a small population of these cancer cells, which exhibit both neuronal-like features and multidrug resistance, likely originate from neural cells, suggesting that ovarian cancer may arise from a neuroepithelial lineage.
In this work, we are reporting that "Shock and Kill", a therapeutic approach designed to eliminate latent HIV from cell reservoirs, is extrapolatable to cancer therapy. This is based on the observation that malignant cells express a spectrum of human endogenous retroviral elements (HERVs) which can be transcriptionally boosted by HDAC inhibitors. The endoretroviral gene HERV-V2 codes for an envelope protein, which resembles syncytins.
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