Recent tropical Andean glacier retreat is unprecedented in the Holocene.

Tropical glaciers have retreated over recent decades, but whether the magnitude of this retreat exceeds the bounds of Holocene fluctuations is unclear. We measured cosmogenic beryllium-10 and carbon-14 concentrations in recently exposed bedrock at the margin of four glaciers spanning the tropical Andes to reconstruct their past extents relative to today. Nuclide concentrations are near zero in almost all samples, suggesting that these locations were never exposed during the Holocene.

A Consistent Framework for Coupling Basal Friction With Subglacial Hydrology on Hard-Bedded Glaciers.

Below hard-bedded glaciers, both basal friction and distributed subglacial drainage are thought to be controlled by a network of cavities. Previous coupled hydro-mechanical models, however, describe cavity-driven friction and hydraulic transmissivity independently, resulting in a physically inconsistent cavity evolution between the two components of the models. Here, we overcome this issue by describing the hydro-mechanical system using a common cavity-evolution description, that governs both transient friction and hydraulic transmissivity.

Rate-and-state friction explains glacier surge propagation.

The incomplete understanding of glacier dynamics is a major source of uncertainty in assessments of sea-level rise from land-based ice. Through increased ice discharge into the oceans, accelerating glacier flow has the potential to considerably enhance expected sea-level change, well ahead of scenarios considered by the IPCC. Central in our incomplete understanding is the motion at the glacier bed, responsible for flow transients and instabilities involving switches from slow to fast flow.

Dynamic vulnerability revealed in the collapse of an Arctic tidewater glacier.

Glacier flow instabilities can rapidly increase sea level through enhanced ice discharge. Surge-type glacier accelerations often occur with a decadal to centennial cyclicity suggesting internal mechanisms responsible. Recently, many surging tidewater glaciers around the Arctic Barents Sea region question whether external forces such as climate can trigger dynamic instabilities.

Natural killer cell responses to dendritic cells infected by the ANRS HIV-1 vaccine candidate, MVAHIV.

Innate mechanisms are critical for the development of the host immune responses to antigen. Particularly, early interaction between natural killer (NK) cells and dendritic cells (DC) greatly impacts the establishment of both innate and adaptive immune responses. In this study, using an autologous in vitro co-culture system we analyzed the NK cell response against MVAHIV-infected DC as well as the subsequent ability of these MVAHIV-primed NK cells to control HIV-1 infection in autologous DC.

S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV-1 replication by NK cells.

Background: The reportedly broad expression of CD85j across different immune cell types suggests an importance for this molecule in the human immune system. Previous reports have shown that this receptor interacts with several HLA class-I molecules, as well as with some viral proteins. We have demonstrated that the subset of CD85j + Natural Killer (NK) cells efficiently controls human immunodeficiency virus type 1 (HIV-1) replication in monocyte-derived dendritic cells (MDDC) in vitro and this led us to hypothesize that the CD85j + NK cell-mediated anti-HIV activity in MDDC is specifically dependent on the interaction between the CD85j receptor and unknown non-HLA class-I ligand(s).