Publications by authors named "Adrien Carmona"
Article Synopsis
- - Pathological tissues produce various substances, including extracellular vesicles (EVs) from active or dying cells.
- - EVs found in diseased heart valves may play a significant role in the development of valve thrombosis.
- - In cases of human aortic stenosis, EVs can activate valvular endothelial cells, causing dysfunction and increasing the chances of blood clotting.
Background: The effects of pharmacological therapy on cardiogenic shock (CS) survivors have not been extensively studied. Thus, this study investigated the association between guideline-directed heart failure (HF) medical therapy (GDMT) and one-year survival rate in patients who are post-CS.
Methods And Results: FRENSHOCK (French Observatory on the Management of Cardiogenic Shock in 2016) registry was a prospective multicenter observational survey, conducted in metropolitan French intensive care units and intensive cardiac care units.
Background: COVID-19 is associated with an increased risk of cardiovascular complications. Although cytokines have a predominant role in endothelium damage, the precise molecular mechanisms are far from being elucidated.
Objectives: The present study hypothesized that inflammation in patients with COVID-19 contributes to endothelial dysfunction through redox-sensitive SGLT2 overexpression and investigated the protective effect of SGLT2 inhibition by empagliflozin.
Article Synopsis
- Transcatheter aortic valve replacement (TAVR) is the preferred treatment for severe aortic stenosis, and a study of 705 patients at Strasbourg University Hospital examined long-term survival rates after the procedure.
- The study found a 45.8% all-cause mortality rate over an average of 5.4 years, with no significant survival differences based on the type of valve used.
- Key factors influencing mortality included being aged 90 or older, having diabetes, experiencing post-TAVR stroke, and acute kidney injury, while more than half of the participants survived beyond 5 years post-procedure.
Background: Cardiovascular disease and cancer are the two leading causes of mortality worldwide, and their association presents a therapeutic challenge. Current data regarding the prognosis of active cancer in patients undergoing transcatheter aortic valve replacement are conflicting.
Aim: To determine the impact and prognosis of active cancer in transcatheter aortic valve replacement.
Background: Bioprosthetic valve thrombosis is a complication of transcatheter aortic valve replacement (TAVR). It is believed to be platelet independent, mainly driven by contact phase activation, and more likely to be targeted by oral anticoagulant (OAC).
Case Summary: We report case of an 86-year-old man with history of TAVR, who presented an early TAVR aortic valve thrombosis occurring in the context of heparin-induced thrombocytopenia (HIT) and pulmonary embolism.
Transcatheter aortic valve implantation (TAVI) has become an alternative to surgical aortic valve replacement for patients with symptomatic severe aortic stenosis in elderly and comorbid population. Significant improvement in heart function has been observed in patients undergoing TAVI, but numerous patients are readmitted to hospital for heart failure (HF). Moreover, repeat HF hospitalization is strongly associated with an adverse prognosis and increases the financial burden of health care.
View Article and Find Full Text PDFBackground: Non-ST elevation acute coronary syndrome (NSTE-ACS) is one of the most frequent manifestations of coronary artery disease. The occurrence of serious heart rhythm disorders (SHRDs) in NSTE-ACS is not well documented. However, continuous heart rhythm monitoring is recommended during the initial management of NSTE-ACS.
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- * The study found that a prolonged closure time of adenosine diphosphate (CT-ADP) after the procedure, defined as greater than 180 seconds, further increased this risk, particularly in patients with AF.
- * Multivariate analysis indicated that AF patients with CT-ADP >180 seconds were 3.9 times more likely to experience MLBCs, highlighting the importance of monitoring hemostatic disorders in this population.
Coronary subclavian steal syndrome causing acute coronary syndrome: a case report.
Eur Heart J Case Rep
September 2022
Background: Myocardial infarction on non-occluded coronary artery represents a very specific subset of acute coronary syndrome (ACS). Coronary subclavian steal syndrome (CSSS) is defined by a left subclavian artery stenosis in case of (i) left internal mammary artery (LIMA) used to bypass left anterior descending artery (LAD) and (ii) >75% stenosis of the left subclavian artery prior to the origin of the LIMA to LAD graft. Here we report the case of a CSSS causing ACS.
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- Bleeding complications are significant after transcatheter aortic valve replacement (TAVR), especially in patients with atrial fibrillation (AF), necessitating effective prediction models for major bleeding events.
- The study focused on post-procedural primary hemostasis disorders measured by CT-ADP values over 180 seconds and their relation to late major/life-threatening bleeding complications (MLBCs) among TAVR patients.
- Results showed that 14.8% of patients had prolonged CT-ADP, which correlated with a significantly higher rate of MLBCs, making it a vital predictor alongside other factors like bleeding history and complications following TAVR.
Article Synopsis
- - The study examined how baseline mean platelet volume (MPV) affects bleeding complications in patients who underwent transcatheter aortic valve replacement (TAVR), with a focus on major/life-threatening bleeding complications (MLBCs) within one year.
- - Among the 1,111 patients analyzed, those with low MPV (≤10 fL) experienced a higher rate of MLBCs (22.9%) compared to those with high MPV (>10 fL, 17.7%). Additionally, L-MPV was linked to more vascular access-site complications and need for red blood cell transfusions.
- - The research concluded that preprocedural MPV is an independent predictor of MLBCs after T
Background: Acute kidney injury (AKI) is associated with a dismal prognosis in Transcatheter Aortic Valve replacement (TAVR). Acute kidney recovery (AKR), a phenomenon reverse to AKI has recently been associated with better outcomes.
Methods: Between November 2012 to May 2018, we explored consecutive patients referred to our Heart Valve Center for TAVR.
Background: Although there is an apparent rapid and spontaneous recovery of left ventricular ejection fraction (LVEF) in patients with Takotsubo syndrome (TTS), recent studies have demonstrated a long-lasting functional impairment in those patients. The present study sought to evaluate the predictors of incomplete recovery following TTS and its impact on cardiovascular mortality.
Methods and results: Patients with TTS between 2008 and 2018 were retrospectively enrolled at 3 different institutions.
Background Electrocardiographic strain pattern (ESP) has recently been associated with increased adverse outcome in aortic stenosis and after surgical aortic valve replacement. Our study sought to determine the impact and incremental value of ESP pattern in predicting adverse outcome after transcatheter aortic valve replacement. Methods and Results A total of 585 patients with severe aortic stenosis (mean age, 83±7 years; men, 39.
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- The study investigates the relationship between D-Dimers levels and lung injury in hospitalized non-critically ill COVID-19 patients, focusing on how elevated D-Dimers can indicate severe lung complications.* -
- Researchers classified patients based on their D-Dimers levels and found that those with higher levels had a significantly increased risk of critical lung injuries and adverse outcomes, such as death or ICU transfer.* -
- The findings suggest that measuring D-Dimers can be a useful prognostic tool for assessing lung health and predicting worse outcomes in COVID-19 patients without thrombotic complications.*
Article Synopsis
- The study investigates the impact of COVID-19 on patients with aortic stenosis who had received transcatheter aortic valve replacement (TAVR) and examines the role of ABO blood groups in disease susceptibility and outcomes.
- Out of 702 patients analyzed, 22 (3.1%) contracted COVID-19, with 63.6% of those being hospitalized or dying as a result of the disease.
- The A blood group was found to be a significant independent predictor for contracting COVID-19, and it also correlated with worse clinical outcomes, alongside a history of cancer.
Aims: Recent insights have emphasized the importance of myocardial and systemic inflammation in Takotsubo syndrome (TTS). In a large registry of unselected patients, we sought to evaluate whether residual high inflammatory response (RHIR) could impact cardiovascular outcome after TTS.
Methods And Results: Patients with TTS were retrospectively included between 2008 and 2018 in three general hospitals.
Article Synopsis
- Reduced left ventricular ejection fraction (LVEF) in patients with acute coronary syndrome (ACS) is linked to a higher risk of hospitalization or death due to COVID-19.
- In a study of 889 patients, those with LVEF below 40% faced a significantly greater incidence of COVID-19-related complications compared to those with better heart function.
- The findings suggest that individuals with reduced LVEF should be prioritized for COVID-19 testing and treatment due to their increased vulnerability.