Publications by authors named "Adriele C Siqueira"
Invasive pneumococcal disease (IPD) is a major cause of morbidity and mortality worldwide, particularly in the pediatric population (children and infants), with high rates of hospitalization and death. This study aimed to create and validate a classifier for serotyping using Fourier-transform infrared (FT-IR) spectroscopy as a rapid alternative to the classical serotyping technique. In this study, a database comprising 76 clinical isolates, including 18 serotypes (predominantly serotypes 19A, 6C, and 3) of from pediatric patients with IPD, was tested at a tertiary pediatric hospital in southern Brazil during 2016-2023.
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- Invasive candidiasis (IC) caused by non-albicans Candida is on the rise globally, especially in pediatrics, but there is limited data on its characteristics and treatment responses in children.
- A study in a southern Brazilian children's hospital analyzed 123 non-duplicate Candida isolates from 2016 to 2021, finding a range of IC incidence between 0.88-1.55 cases per 1000 hospitalized patients and a mortality rate of 20.3%, with many cases occurring in patients under 13 months and linked to ICU admissions.
- The research noted that the predominant species were non-albicans Candida (70.8%), with most isolates producing biofilm, but there was no significant clonal
Carbapenem-resistant Klebsiella pneumoniae (CRKP) exhibit high mortality rates in pediatric patients and usually belong to international high-risk clones. This study aimed to investigate the molecular epidemiology and carbapenem resistance mechanisms of K. pneumoniae isolates recovered from pediatric patients, and correlate them with phenotypical data.
View Article and Find Full Text PDFObjectives: We aimed to investigate an outbreak of vancomycin-resistant Enterococcus faecium (VREfm) in paediatric patients from Hospital Pequeno Príncipe. The susceptibility profile was determined, and whole-genome sequencing (WGS) was used to analyse the genetic context of the strains.
Methods: Five VREfm isolates were recovered from sterile sites and surveillance cultures of two paediatric patients with acute lymphoblastic leukaemia.
Invasive candidiasis (IC) contributes to the morbidity and mortality of hospitalized patients and represents a significant burden to the healthcare system. Previous Brazilian studies have reported the presence of endemic sensu stricto genotypes causing candidemia and clonal transmission involving fluconazole-resistant isolates. We performed a 5-year retrospective analysis of IC cases in a Brazilian tertiary pediatric hospital and conducted a molecular investigation of sensu stricto.
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