Publications by authors named "Adrianne M de Roo"

Background: Chikungunya virus (CHIKV) outbreaks, driven by the expanding habitat of the Aedes albopictus mosquito and global climate change, pose a significant threat to public health. Our study evaluates the effectiveness of emergency vaccination using a dynamic disease transmission model for a potential large-scale outbreak in Rome, Italy.

Methods: The model incorporates a susceptible-exposed-infected-recovered (SEIR) framework for human and mosquito populations, taking into account temperature-dependent mosquito lifecycle dynamics, human-mosquito interactions, and various vaccination scenarios.

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Article Synopsis
  • * Between 2011 and 2020, there were 18.7 million chikungunya cases globally, resulting in 1.95 million disability-adjusted life years (DALYs), primarily affecting the Latin American and Caribbean regions.
  • * The economic impact over this period was substantial, with direct costs of $2.8 billion and indirect costs reaching $47.1 billion, highlighting the need for effective resource allocation to manage this disease.
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Background: Chikungunya is a viral disease caused by a mosquito-borne alphavirus. The acute phase of the disease includes symptoms such as fever and arthralgia and lasts 7-10 days. However, debilitating symptoms can persist for months or years.

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