Publications by authors named "Adriane Lentz-Hommertgen"
Background: Stereotactic Radiosurgery (SRS) is an emerging alternative to whole-brain radiotherapy (WBRT) for treating multiple brain metastases (BM), reducing toxicity and improving tumor control. The CYBER-SPACE trial compared SRS based on either SPACE or MPRAGE MRI sequence for avoiding or delaying WBRT in patients with 1-10 BM.
Methods: Patients with 1-10 untreated BM were randomized 1:1 to receive SRS of all lesions based on either SPACE or MPRAGE MRI sequences.
Introduction: Sacrococcygeal chordomas have high recurrence rates and are challenging to treat.
Methods: In this phase II prospective, randomized, stratified trial, the safety and feasibility of hypofractionated ion radiation therapy were investigated. The primary focus was monitored through the incidence of Grade 3-5 NCI-CTC-AE toxicity.
Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07).
BMC Cancer
April 2024
Background: While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring.
View Article and Find Full Text PDFPurpose: After radical prostatectomy (RP), adjuvant or salvage radiation treatment in node-positive prostate cancer is offered to prevent systemic disease. Prospective long-term survival and toxicity data on patients with radiation for nodal disease are still scarce. This study evaluates safety and feasibility of salvage radiation therapy to the pelvic lymph nodes in node-positive prostate cancer after RP.
View Article and Find Full Text PDFArticle Synopsis
- A study aimed to assess the effects of two types of dental appliances on oral health after head and neck radiotherapy, comparing thermoplastic dental splints with semi-individualized, 3D-printed tissue retraction devices (TRDs).
- The pilot trial included 29 patients, measuring saliva quality, taste perception, and oral disability before and three months after starting treatment.
- Results showed no significant differences in taste perception or oral disability between the two groups, but TRDs suggested a slight advantage in saliva quantity and overall outcomes, although the small sample size warrants caution in interpreting these findings.